🔥 Gut Health · Inflammatory Bowel Disease

IBD is not a condition you manage. It is a molecular imbalance you can resolve.

Crohn’s disease and ulcerative colitis are driven by a measurable dysregulation of your oral & gut microbiome — a chronic breakdown in the interaction between your microbial ecosystem and your immune system. Genefitletics decodes the specific biochemical pathways driving that breakdown, before disease progresses and quality of life declines.

India’s IBD Reality
1.5Mn+
Indians estimated to have IBD — a number rising rapidly with urbanisation, dietary shifts and gut microbiome disruption
400+
Biological pathways we measure — encompassing 10,000+ biochemical functions across your gut and oral microbiome
2Bn+
Molecular and longitudinal data points collected over 4 years — enabling us to develop predictive biomarkers for IBD at stage 0–1
Based on ICMR 2024 & Genefitletics molecular data architecture
Go beyond colonoscopy & calprotectin tests

IBD is a molecular problem

Your gut microbiome programmes intestinal inflammation at the level of gene expression.

The interaction between your external environment and your oral & gut microbiome and mitochondria triggers breakdown in energetic process of the mitochondria stimulating a cascade of biochemical functions that programme your intestinal lining for either homeostasis or chronic inflammation. In IBD, this cascade is dysregulated at its root.

Working at the confluence of next-generation sequencing and machine learning, our system biology platform goes beyond static DNA and collects, processes and translates 10 million molecular data points per sample — elucidating the early molecular signatures of Crohn’s disease and ulcerative colitis, and identifying the precise therapeutics targets needed to re-establish metabolic homeostasis in the gut.

IBD is not caused by the presence of harmful bacteria — it is caused by the breakdown of the functional relationship between your microbiome and your immune system. An imbalanced oral and gut microbiome generates pathogenic metabolites that breach the intestinal mucosal barrier, triggering a self-perpetuating inflammatory cascade that is the defining mechanism of both Crohn’s disease and ulcerative colitis.
Gut Dysbiosis Model Butyrate & Mucosal Barrier LPS & Leaky Gut Pathways Stage 0–1 Detection
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Butyrate deficiency breaks down the mucosal barrier
Reduced butyrate production by gut microbiota directly weakens the intestinal epithelial barrier — allowing luminal antigens and microbial metabolites to cross into the lamina propria and trigger the innate immune response central to IBD.
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LPS from gut dysbiosis drives systemic immune activation
Lipopolysaccharide (LPS) produced by gram-negative gut bacteria enters the bloodstream through a leaky gut — activating TLR4 receptors and initiating a systemic inflammatory cascade that perpetuates intestinal inflammation in IBD.
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Histamine overproduction amplifies gut inflammation
Certain gut bacteria produce excess histamine — a key inflammatory mediator that increases intestinal permeability, activates mast cells and amplifies the mucosal immune response driving IBD flares.
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IBD disrupts the gut–brain axis
Chronic intestinal inflammation dysregulates the gut–brain signalling pathway — elevating anxiety, depression and cortisol, which in turn amplifies immune dysregulation and worsens disease activity in a measurable feedback loop.

ORAHYG PRO — Full Body Biochemistry Solution

Our unique test measures your microbiome & cellular functions to predict & prevent Inflammatory Bowel Disease.

Our full-body biochemistry solution empowers you and your healthcare practitioners with deeper insight about your oral and gut microbiome at molecular level — identifying hard-to-detect early molecular signatures for IBD and delivering the most comprehensive gut health insights available.

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Data Collection & Analysis
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  • Easy at-home saliva sample collection
  • Detailed view of your overall health at molecular level via 70+ biological pathway scores & 10 whole-body scores
  • Decode the underlying molecular cause of gut inflammation and intestinal barrier breakdown
  • Access to a computational biology platform for your healthcare practitioners
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Disease Prediction
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  • Predict onset of IBD, Gum Disease & Oral Cavities
  • Identify butyrate deficiency, LPS overproduction and histamine dysregulation before intestinal damage occurs
  • Detect molecular dysregulation before conventional diagnostics can detect it
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Disease Modifiable Interventions
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  • Molecular data-driven precision nutrition, supplement, biotics & oral hygiene interventions
  • Support health functions tied to gut lining integrity, immune regulation, metabolic health & more
  • Real-time monitoring at regular intervals to revise interventions aligned with your current biochemistry
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Technology Tools
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  • Efficacy mapping via clinically validated questionnaires to assess the impact of the nutritional therapeutics programme on health outcomes
  • Personalised nutrition planner eliminating the need for a nutritionist or health coach
Annual Subscription
ORAHYG PRO
Full Body Biochemistry · IBD Prediction · Gut Health
Sample Saliva
Health Scores 72
Results In 4 weeks
Prediction Models 4
Age Eligibility 9+ years

At-Home Testing Process

Four simple steps to your gut health molecular report.

No clinic visit. No colonoscopy. A simple at-home saliva sample and 4 weeks to a complete molecular picture of the biology driving your gut inflammation.

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Sign up & receive your kit
Subscribe to ORAHYG PRO and your at-home saliva sample collection kit is shipped to your registered address.
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Collect your saliva sample
Follow the included instructions to collect your saliva sample. We arrange pick-up within 24–36 hours of your confirmation.
3
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Complete your phenotype form
Fill your scientifically designed digital phenotype form capturing your current health conditions, allergies and lifestyle.
4
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Receive your insights & recommendations
Access your complete gut health scores, IBD molecular pathway insights and personalised precision recommendations in 4 weeks.

What’s Covered

Your complete gut & intestinal health molecular picture.

Get a digital twin of your biology at molecular level with Asia’s first and only system biology platform analysing the downstream biochemical functions of your oral and gut microbiome combined with cellular health.

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Full Body Molecular Insights
Gut + Oral Microbiome + Cellular Health

70+ personalised molecular health insights and scores that reveal your IBD risk at molecular level — identifying the specific butyrate, LPS and inflammatory pathway dysfunctions driving gut inflammation, and forming the basis of precision nutrition as medicine. Track improvements in your pathway scores at re-sequencing after 12 months.

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Whole Body Scores
10 systemic health dimensions
  • Gut Health
  • Oral Health
  • Skin Health
  • Heart & Metabolic Health
  • Brain & Cognitive Health
  • Stress Response
  • Immune System Health
  • Hormonal Health
  • Inflammation Response
  • Energy Efficiency
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Oral Pathway Scores
25+ oral microbiome pathways
  • Oral H2S
  • Oral Methyl Mercaptan Production
  • Oral Polyamines Production
  • Oral Ammonia Production
  • Oral Urease Pathways
  • Oral Butyrate Production
  • Oral Inflammatory Pathways
  • Oral Nitric Oxide Production
  • Oral Cavities Promoting Pathways
& 25 more pathway scores
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Gut Pathway Scores
19+ gut microbiome pathways
  • Butyrate Production
  • Oxalate Metabolism
  • Histamine Overproduction
  • Antioxidant Score
  • LPS Production
  • TMAO Production
& 19 more pathway scores
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Cellular Pathway Scores
Mitochondrial & cellular health
  • Cellular Senescence
  • Cellular Stress
  • Energy Efficiency
  • Immune Health
  • Biological Age
  • Triglyceride Homeostasis
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Amino Acid Metabolism
7 key amino acid pathways
  • Arginine Metabolism
  • Lysine Metabolism
  • Threonine Metabolism
  • Tyrosine Metabolism
  • Tryptophan Metabolism
  • Phenylalanine Metabolism
  • Histidine Metabolism
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Mitochondrial Pathways
Intestinal energy & cellular function
  • Cytokine Signalling
  • Mitochondrial Respiration Process
  • Energy Resistance

Unravelling Your Molecular Biochemistry

Three biological sources. One complete picture of your gut health.

We go beyond which microbes are present — measuring and quantifying the downstream biochemical functions of your microbiome and mitochondria to decode the actual molecular mechanisms driving your IBD risk.

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Gut Microbiome
The ecosystem of microbes in the large intestine. Gut microbiome-derived metabolites play a pivotal role in regulating mucosal barrier integrity, immune tolerance and intestinal inflammation — all central to IBD onset and progression.
Biochemical functions, not microbial diversity ▾
We go beyond microbial DNA and measure downstream functions performed by bacteria, fungi, viruses, phages and yeast living in your gut. Our analysis covers 400+ biological pathways encompassing 10,000+ biochemical functions. We do not categorise microbes as simply good or bad — many commensal microbes perform both beneficial and harmful activities depending on the genes they express and their interaction with the external environment.
400+ Pathways Functional Analysis
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Oral Microbiome
The most dense microbiome ecosystem in the body. Emerging evidence confirms the oral microbiome plays a direct role in gut health — dysbiotic oral pathogens are found in increased abundance in IBD patients and directly amplify intestinal inflammation.
How oral microbes drive gut inflammation ▾
Imbalanced oral microbiome leads to biofilm formation — pathogens secrete toxic byproducts that are swallowed and colonise the gut, directly disrupting the intestinal microbiome composition and amplifying mucosal inflammation. Research confirms that oral dysbiosis precedes gut dysbiosis in IBD patients, making oral microbiome measurement a critical early detection window. ORAHYG PRO measures these oral microbial pathways to identify IBD risk early and deliver targeted interventions.
ORAHYG PRO Oral–Gut Axis
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Mitochondrial Function
Mitochondrial efficiency is central to gut health. Intestinal epithelial cells have extremely high energy demands — mitochondrial dysfunction driven by chronic inflammation directly impairs mucosal barrier repair and perpetuates IBD flares.
How mitochondria impact gut inflammation ▾
When intestinal epithelial cell mitochondria become dysfunctional due to ongoing inflammation and oxidative stress, ATP production declines — impairing tight junction maintenance, mucus production and the repair mechanisms that keep the gut lining intact. This creates a feedback loop of worsening barrier breakdown and sustained inflammation. We measure mitochondrial pathway scores and deliver biotherapeutics that restore cellular energy efficiency and support mucosal healing.
Energy Efficiency Cellular Health

Start Your Gut Health Journey

Don’t wait for your gut to break down. Act now.

Get your personalised IBD risk score, understand the molecular pathways driving your gut inflammation, and receive precision interventions to prevent the onset of Inflammatory Bowel Disease — all from a simple at-home saliva sample.

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Genefitletics

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