โš–๏ธ Weight Management ยท Metabolic Health

You are not overweight. Your biology is out of balance.

Generic diets treat weight as a calorie problem. Genefitletics treats it as a molecular one โ€” decoding the gut microbiome pathways, metabolic dysfunctions and inflammatory signals that are actually driving your body’s resistance to weight loss.

India’s Metabolic Weight Crisis
268Mn+
Indians are overweight or obese โ€” yet most weight loss interventions address symptoms, not the molecular root cause
40Tn
Microbes in your gut ecosystem โ€” governing your satiety signals, metabolic rate, fat storage and insulin response
300+
Foods mapped for your personalised glycaemic and metabolic response โ€” precision nutrition, not guesswork
Based on ICMR 2024 & Genefitletics molecular data architecture
Decode your biology. Don’t just count calories.

Weight is a molecular problem

Your gut microbiome is the hidden regulator of your weight.

The interaction between your external environment and your unique gut microbiome triggers gene expression that codes for proteins โ€” inhibiting or stimulating a cascade of biochemical functions that program your biology for either metabolic health or weight gain.

Generic dietary recommendations โ€” Paleo, Keto, calorie counting โ€” work in isolation and miss the fundamental driver: your individual biochemistry. All macronutrients are necessary for balanced biological function. The solution for healthy weight management lies in decoding which specific foods are aligned with your unique molecular biology.

Beneficial microbial activities + Diverse Gut Flora = Healthy Gut Microbiome = Healthy Weight. When your gut microbiome is balanced, it extracts maximum benefit from food โ€” transforming nutrients into short-chain fatty acids that strengthen your gut lining, regulate appetite hormones and optimise fat metabolism at cellular level.
Microbiome-Driven Weight Loss Precision Nutrition LPS & Cortisol Pathways 300+ Foods Mapped
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Imbalanced microbiome drives fat storage
Dysbiosis triggers release of lipopolysaccharides (LPS) into the bloodstream โ€” a direct molecular driver of systemic inflammation, insulin resistance and abdominal fat storage.
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The gutโ€“brain axis & stress weight gain
Imbalanced gut microbiome disrupts gut-brain signalling โ€” elevating cortisol, increasing insulin resistance and triggering appetite dysregulation that drives chronic weight gain.
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Mitochondrial dysfunction slows metabolism
Dysfunctional mitochondria reduce cellular energy efficiency โ€” impairing the metabolic rate and glucose utilisation that are essential for healthy weight management.
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Precision nutrition, not generic diets
We mathematically combine 400+ molecular pathways with 40,000+ nutrition substrates to construct interventions that are unique to your individual biochemistry โ€” not population averages.

ORAHYG PRO โ€” Full Body Biochemistry Solution

Our unique test measures your microbiome & cellular functions to decode & resolve the root cause of weight gain.

Our full-body biochemistry solution empowers you and your healthcare practitioners with molecular-level insight into the gut and oral microbiome pathways governing your metabolism, satiety signalling and fat storage โ€” delivering the most comprehensive weight management insights available.

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Data Collection & Analysis
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  • Easy at-home saliva sample collection
  • Detailed view of your overall health at molecular level via 70+ biological pathway scores & 10 whole-body scores
  • Decode the underlying molecular cause of metabolic dysfunction and weight gain
  • Access to a computational biology platform for your healthcare practitioners
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Disease Prediction
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  • Predict onset of Type 2 Diabetes, Cardiovascular Diseases, Chronic Kidney Disease, IBD, Gum Disease & Oral Cavities
  • Predict your personalised insulin response to 300+ foods โ€” making CGM redundant
  • Detect metabolic dysregulation before conventional diagnostics can detect it
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Disease Modifiable Interventions
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  • Molecular data-driven precision nutrition, supplement, biotics & oral hygiene interventions
  • Support health functions tied to metabolism, blood sugar regulation, gut health & more
  • Real-time monitoring at regular intervals to revise interventions aligned with your current biochemistry
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Technology Tools
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  • Efficacy mapping via clinically validated questionnaires to assess the impact of the nutritional therapeutics programme on health outcomes
  • Personalised nutrition planner eliminating the need for a nutritionist or health coach
Annual Subscription
ORAHYG PRO
Full Body Biochemistry ยท Metabolic Health ยท Weight Management
Sample Saliva
Health Scores 72
Results In 4 weeks
Prediction Models 4
Foods Mapped 300+
Age Eligibility 9+ years

At-Home Testing Process

Four simple steps to your molecular weight management report.

No clinic visit. No blood draws. A simple at-home saliva sample and 4 weeks to a complete molecular picture of the biology driving your weight.

1
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Sign up & receive your kit
Subscribe to ORAHYG PRO and your at-home saliva sample collection kit is shipped to your registered address.
2
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Collect your saliva sample
Follow the included instructions to collect your saliva sample. We arrange pick-up within 24โ€“36 hours of your confirmation.
3
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Complete your phenotype form
Fill your scientifically designed digital phenotype form capturing your current health conditions, allergies and lifestyle.
4
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Receive your insights & recommendations
Access your complete metabolic pathway scores, weight-relevant molecular insights and personalised precision nutrition recommendations in 4 weeks.

What’s Covered

Your complete metabolic & weight management molecular picture.

Get a digital twin of your biology at molecular level with Asia’s first and only system biology platform analysing the downstream biochemical functions of your oral and gut microbiome combined with cellular health.

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Full Body Molecular Insights
Gut + Oral Microbiome + Cellular Health

70+ personalised molecular health insights and scores that reveal the biological root cause of your weight at molecular level โ€” identifying the specific inflammatory and metabolic pathway dysfunctions driving weight gain, and forming the basis of precision nutrition as medicine. Track improvements at re-sequencing after 12 months.

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Whole Body Scores
10 systemic health dimensions
  • Gut Health
  • Oral Health
  • Skin Health
  • Heart & Metabolic Health
  • Brain & Cognitive Health
  • Stress Response
  • Immune System Health
  • Hormonal Health
  • Inflammation Response
  • Energy Efficiency
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Oral Pathway Scores
25+ oral microbiome pathways
  • Oral H2S
  • Oral Methyl Mercaptan Production
  • Oral Polyamines Production
  • Oral Ammonia Production
  • Oral Urease Pathways
  • Oral Butyrate Production
  • Oral Inflammatory Pathways
  • Oral Nitric Oxide Production
  • Oral Cavities Promoting Pathways
& 25 more pathway scores
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Gut Pathway Scores
19+ gut microbiome pathways
  • Butyrate Production
  • Oxalate Metabolism
  • Histamine Overproduction
  • Antioxidant Score
  • LPS Production
  • TMAO Production
& 19 more pathway scores
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Cellular Pathway Scores
Mitochondrial & cellular health
  • Cellular Senescence
  • Cellular Stress
  • Energy Efficiency
  • Immune Health
  • Biological Age
  • Triglyceride Homeostasis
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Amino Acid Metabolism
7 key amino acid pathways
  • Arginine Metabolism
  • Lysine Metabolism
  • Threonine Metabolism
  • Tyrosine Metabolism
  • Tryptophan Metabolism
  • Phenylalanine Metabolism
  • Histidine Metabolism
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Mitochondrial Pathways
Metabolic energy & cellular function
  • Cytokine Signalling
  • Mitochondrial Respiration Process
  • Energy Resistance

Unravelling Your Molecular Biochemistry

Three biological sources. One complete picture of your metabolic health.

We go beyond which microbes are present โ€” measuring and quantifying the downstream biochemical functions of your microbiome and mitochondria to decode the actual molecular mechanisms driving your weight.

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Gut Microbiome
The ecosystem of microbes in the large intestine. Gut microbiome-derived metabolites play a pivotal role in regulating satiety signalling, fat metabolism, insulin sensitivity and systemic inflammation โ€” all central to weight management.
Biochemical functions, not microbial diversity โ–พ
We go beyond microbial DNA and measure downstream functions performed by bacteria, fungi, viruses, phages and yeast living in your gut. Our analysis covers 400+ biological pathways encompassing 10,000+ biochemical functions. We categorise microbes by whether they are performing harmful or beneficial activities โ€” not as simply good or bad.
400+ Pathways Functional Analysis
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Oral Microbiome
The most dense microbiome ecosystem in the body. Emerging evidence confirms the oral microbiome plays a direct role in regulating metabolic health โ€” an often overlooked driver of systemic inflammation, insulin resistance and weight gain.
How oral microbes drive metabolic dysfunction โ–พ
Imbalanced oral microbiome leads to biofilm and plaque formation. Pathogens secrete toxic byproducts into the bloodstream โ€” triggering leaky gut, systemic inflammation and directly impairing insulin signalling. Research confirms links between oral dysbiosis, obesity, type 2 diabetes and cardiovascular disease. ORAHYG PRO measures these oral microbial pathways to identify metabolic dysfunction early and deliver targeted interventions.
ORAHYG PRO Leaky Gut Pathways
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Mitochondrial Function
Mitochondrial efficiency is central to metabolic health. Dysfunctional mitochondria impair cellular energy production โ€” directly reducing the metabolic rate and cellular capacity to utilise glucose and fat efficiently.
How mitochondria impact weight & metabolism โ–พ
When mitochondria become dysfunctional due to ongoing inflammation and oxidative stress, cellular energy production declines โ€” impairing glucose uptake and fat oxidation. This creates a feedback loop of worsening metabolic dysfunction and weight gain. We measure mitochondrial pathway scores and deliver biotherapeutics that restore cellular energy efficiency.
Energy Efficiency Cellular Health

Start Your Metabolic Health Journey

Stop fighting your biology. Work with it.

Get your personalised metabolic health scores, glycaemic response for 300+ foods, and precision interventions that address the molecular root cause of your weight โ€” all from a simple at-home saliva sample.

Genefitletics

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