Kidney Health · Chronic Kidney Disease

Identify Renal Dysfunction before your blood works show abnormalities.

Chronic Kidney Disease develops silently — 90% of sufferers have no symptoms until significant function is already lost. Genefitletics measures the mitochondrial, gut and oral microbiome-derived cellular pathways that programme kidney inflammation and damage, years before creatinine and eGFR tests flag a problem.

India’s CKD Crisis
17%
Indians are estimated to have Chronic Kidney Disease — driven by a rising tide of diabetes, hypertension and systemic inflammation
90%
Of CKD patients have no symptoms in early stages — making molecular early detection the only window for intervention
5stages
CKD is divided into 5 stages. By stage 3, 50% of kidney function is already lost. Our molecular model detects risk at stage 0–1
Based on ICMR 2024 & Genefitletics molecular data architecture
Go beyond creatinine & eGFR tests

CKD is a mitochondrial problem

Breakdown in mitochondrial functions programmes kidney inflammation years before symptoms appear.

External stressors & microbial metabolites could lead to breakdown in energetic process of the mitochondria resulting in oxidative stress, reductive stress and renal dysfunction. Conventional diagnostics — creatinine, eGFR, urinalysis — measure what has already been lost. Genefitletics measures the cellular signals driving that loss, before it happens.

Working at the confluence of next-generation sequencing and machine learning, our biophysics & bioenergetics platform collects, processes and translates 10 million molecular data points per sample — elucidating early molecular signatures for CKD and identifying therapeutics targets to re-establish metabolic homeostasis and protect kidney function.

Mitochondrial stress triggers renal dysfunction. Interaction between external environment including nutrition and microbiome (gut & oral) could lead to production of uremic toxins that could disrupt the flow of electrons in the electron transport chain of mitochondria of kidney cells. This leads to leakage of electrons on the moleular oxygen causing oxidative stress. This causes cellular damage, appoptosis, and fibrosis in kidney leading to renal dysfunction.
NEPHROPATH Model Uremic Toxin Pathways Oxalate & LPS Mechanisms Stage 0–1 Detection
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Uremic toxins from gut dysbiosis damage kidneys directly
Imbalanced gut microbiome generates indoxyl sulphate, p-cresyl sulphate and TMAO — uremic toxins that enter the bloodstream and directly accelerate glomerular and tubulointerstitial damage.
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Oxalate overproduction drives kidney stone formation
Dysbiotic gut microbiome with reduced Oxalobacter formigenes activity leads to excess oxalate absorption — a primary driver of calcium oxalate kidney stone formation and progressive nephron damage.
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CKD, diabetes & cardiovascular disease share a molecular root
The same pro-inflammatory microbiome pathways — LPS production, chronic systemic inflammation, insulin resistance — drive Type 2 Diabetes, CKD and cardiovascular disease simultaneously.
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Mitochondrial dysfunction impairs renal tubular energy production
Renal tubular cells are among the most energy-demanding in the body. Mitochondrial dysfunction driven by oxidative stress and chronic inflammation directly impairs tubular transport and accelerates CKD progression.

ORAHYG PRO — Full Body Biochemistry Solution

Our unique test measures your microbiome & cellular functions to predict & prevent Chronic Kidney Disease.

Our full-body biochemistry solution empowers you and your healthcare practitioners with deeper insight about your oral and gut microbiome at molecular level — identifying hard-to-detect early molecular signatures for CKD and delivering the most comprehensive kidney health insights available.

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Data Collection & Analysis
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  • Easy at-home saliva sample collection
  • Detailed view of your overall health at molecular level via 70+ biological pathway scores & 10 whole-body scores
  • Decode the underlying molecular cause of kidney inflammation and disease onset
  • Access to a computational biology platform for your healthcare practitioners
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Disease Prediction
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  • Predict onset of Chronic Kidney Disease
  • Identify uremic toxin-producing pathways and oxalate metabolism dysregulation before kidney function declines
  • Detect molecular dysregulation before conventional diagnostics can detect it
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Disease Modifiable Interventions
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  • Molecular data-driven precision nutrition, supplement, biotics & oral hygiene interventions
  • Support health functions tied to kidney function, blood pressure regulation, gut health & metabolic health
  • Real-time monitoring at regular intervals to revise interventions aligned with your current biochemistry
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Technology Tools
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  • Efficacy mapping via clinically validated questionnaires to assess the impact of the nutritional therapeutics programme on health outcomes
  • Personalised nutrition planner eliminating the need for a nutritionist or health coach
Annual Subscription
ORAHYG PRO
Full Body Biochemistry · CKD Prediction · Kidney Health
Sample Saliva
Health Scores 72
Results In 4 weeks
Prediction Models 4
Age Eligibility 9+ years

At-Home Testing Process

Four simple steps to your kidney health molecular report.

No clinic visit. No blood draws. A simple at-home saliva sample and 4 weeks to a complete molecular picture of your CKD risk and kidney health.

1
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Sign up & receive your kit
Subscribe to ORAHYG PRO and your at-home saliva sample collection kit is shipped to your registered address.
2
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Collect your saliva sample
Follow the included instructions to collect your saliva sample. We arrange pick-up within 24–36 hours of your confirmation.
3
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Complete your phenotype form
Fill your scientifically designed digital phenotype form capturing your current health conditions, allergies and lifestyle.
4
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Receive your insights & recommendations
Access your complete kidney health scores, molecular pathway insights and personalised precision recommendations in 4 weeks.

What’s Covered

Your complete kidney health molecular picture.

Get a digital bioatlas of your biology at molecular level with Asia’s first and only system biology platform analysing the downstream biochemical functions of your oral and gut microbiome combined with cellular health.

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Full Body Molecular Insights
Gut + Oral Microbiome + Cellular Health

70+ personalised molecular health insights and scores that reveal your CKD risk at molecular level — identifying early molecular signatures for kidney damage and forming the basis of precision nutrition as medicine. Track improvements in your pathway scores at re-sequencing after 12 months.

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Whole Body Scores
10 systemic health dimensions
  • Gut Health
  • Oral Health
  • Skin Health
  • Heart & Metabolic Health
  • Brain & Cognitive Health
  • Stress Response
  • Immune System Health
  • Hormonal Health
  • Inflammation Response
  • Energy Efficiency
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Oral Pathway Scores
25+ oral microbiome pathways
  • Oral H2S
  • Oral Methyl Mercaptan Production
  • Oral Polyamines Production
  • Oral Ammonia Production
  • Oral Urease Pathways
  • Oral Butyrate Production
  • Oral Inflammatory Pathways
  • Oral Nitric Oxide Production
  • Oral Cavities Promoting Pathways
& 25 more pathway scores
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Gut Pathway Scores
19+ gut microbiome pathways
  • Butyrate Production
  • Oxalate Metabolism
  • Histamine Overproduction
  • Antioxidant Score
  • LPS Production
  • TMAO Production
& 19 more pathway scores
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Cellular Pathway Scores
Mitochondrial & cellular health
  • Cellular Senescence
  • Cellular Stress
  • Energy Efficiency
  • Immune Health
  • Biological Age
  • Triglyceride Homeostasis
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Amino Acid Metabolism
7 key amino acid pathways
  • Arginine Metabolism
  • Lysine Metabolism
  • Threonine Metabolism
  • Tyrosine Metabolism
  • Tryptophan Metabolism
  • Phenylalanine Metabolism
  • Histidine Metabolism
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Mitochondrial Pathways
Renal energy & cellular function
  • Cytokine Signalling
  • Mitochondrial Respiration Process
  • Energy Resistance

Unravelling Your Molecular Biochemistry

Three biological sources. One complete picture of your kidney health.

We go beyond which microbes are present — measuring and quantifying the downstream biochemical functions of your microbiome and mitochondria to decode the actual molecular mechanisms driving your CKD risk.

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Gut Microbiome
The ecosystem of microbes in the large intestine. Gut microbiome-derived metabolites play a pivotal role in regulating systemic inflammation, uremic toxin production and oxalate metabolism — all central to CKD onset and progression.
Biochemical functions, not microbial diversity ▾
We go beyond microbial DNA and measure downstream functions performed by bacteria, fungi, viruses, phages and yeast living in your gut. Our analysis covers 400+ biological pathways encompassing 10,000+ biochemical functions. We categorise microbes by whether they are performing harmful or beneficial activities — not as simply good or bad.
400+ Pathways Functional Analysis
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Oral Microbiome
The most dense microbiome ecosystem in the body. Emerging evidence confirms the oral microbiome plays a direct role in kidney health — an often overlooked driver of systemic inflammation that accelerates CKD progression.
How oral microbes drive kidney damage ▾
Imbalanced oral microbiome leads to biofilm and plaque formation — pathogens secrete toxic byproducts into the bloodstream, triggering systemic inflammation and endothelial dysfunction that impairs renal filtration. Periodontal disease is clinically associated with accelerated CKD progression and higher risk of kidney failure. ORAHYG PRO measures these oral microbial pathways to identify kidney health risk early and deliver targeted interventions.
ORAHYG PRO Renal Inflammation
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Mitochondrial Function
Mitochondrial efficiency is central to kidney health. Renal tubular cells have exceptionally high energy demands — mitochondrial dysfunction driven by inflammation directly impairs tubular transport and accelerates nephron loss.
How mitochondria impact kidney function ▾
When mitochondria become dysfunctional due to ongoing inflammation and oxidative stress, ATP production declines — impairing the active transport mechanisms that renal tubular cells depend on to filter waste, reabsorb nutrients and regulate fluid balance. This creates a feedback loop of worsening nephron damage and progressive kidney failure. We measure mitochondrial pathway scores and deliver biotherapeutics that restore cellular energy efficiency.
Energy Efficiency Cellular Health

Start Your Kidney Health Journey

Identify cellular stressors causing breakdown in mitochondrial functions eGFR and Cystatin C to decline. Act now.

Get your personalised CKD risk score, understand the molecular pathways driving kidney inflammation, and receive precision interventions to prevent the onset of Chronic Kidney Disease — all from a simple at-home saliva sample.

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Genefitletics

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