Our Science - Genefitletics

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Our goal is to use exponential technologies that bridges the gap between application of scientific discoveries & human health

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We are redefining how people will measure their health with focus on preventive & predictive medicine

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Our system biology approach eliminates the disease causing molecules before symptom appear

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We are transforming healthcare system from managing diseases to early detection & disease modifying precision therapeutics

Underpinning the science behind preventative health

Genefitletics goes beyond human DNA & Microbial taxonomy & standard diagnostic tests to measure biology & chemistry at molecular level with the objective of predicting, preventing & curing chronic diseases & cancer.

Our driving force for better health & longevity includes:

Consumer health innovation- Prevention

Our direct to customer system biology platform- Proteba, analyzes downstream functions of gut & oral microbiome to measure personalized molecular insights & personalize nutrition as medicine to bring body back into homeostasis.

Our disease modifying interventions constructs most precise nutrition interventions based on unique biochemical individuality of each individual.

Disease Prediction

The platform collects & analyzes human microbiome functions data, phenotype data & longitudinal data to measure hard to detect & asymptomatic disease prediction signatures which cannot be identified by standard diagnostic tests for range of chronic diseases & cancer.

Leading molecular data driven human health revolution

We measure 5 mn + data points from downstream functions of gut & oral microbiome which enables us to measure & quantify microbial pathways. Our platform then marries these pathways with food substrates to suppress & promote biology functions to re-establish homeostasis.

We quantify biochemical pathways & establish a correlation with different biological functions that impacts your overall health.

Get access to following pathways

UP THE GUT

Whole Body Scores

Gut Health

Overall Gas Production

Brain & Cognitive Health

Heart & Metabolic Health

Skin Health

Digestive Efficiency

Hormonal Health

Immune System Health

Inflammation Response

Stress Response

Energy Efficiency

Digital Footprint Scores

Butyrate Production

Oxalate Metabolism

Cholesterol Metabolism

Cortisol Production

Fight Or Flight Response

Thyroxine Production

Antioxidant Production

Serotonin Production

COQ10 Production

GABA Production

Ammonia Gas Production

Methane Gas Production

H2S Production

Bile Acid Metabolism

TMA Production

Uric Acid Production

Putrescine Production

Salt Stress Pathways

Candida Overgrowth

Histamine Overproduction

LPS Production

ORAHYG

Whole Body Scores

Breath Assessment

Dental Health

Gum Health

Oral Health

Biological Scores

Oral Butyrate Production Score

Oral Nitric Oxide Production Score

Oral H2S Score

Oral Methyl Mercaptan Production Score

Oral Polyamines Production Score

Oral Ammonia Production Score

Oral Urease Pathways Score

Oral Inflammatory Pathways Score

Oral Cavities Promoting Pathways Score

Succinic Acid Production Score

Lactic Acid Production Score

Biofilm Formation Pathways Score

Oral LPS Production Score

Oral TMAO Production Score

Oral Uric Acid Production Score

Mucin Degradation Pathways Score

Protease Pathways Score

Genotoxic Potential

Pathobiont Activity-1 Score

Pathobiont Activity-2 Score

Fungal Activity Score

Stress Response Score

Lill’Bio

Whole Body Scores

Gut Health

Overall Gas Production

Brain & Cognitive Health

Heart & Metabolic Health

Skin Health

Digestive Efficiency

Hormonal Health

Immune System Health

Inflammation Response

Stress Response

Energy Efficiency

Biological Scores

Metabolic Health Infant Matrix

Neonatal Neurodevelopmental Score

Child Gut Type

HMO Digestion Matrix

Butyrate Production

Oxalate Metabolism

Cholesterol Metabolism

Cortisol Production

Fight Or Flight Response

Thyroxine Production

Antioxidant Production

Serotonin Production

COQ10 Production

GABA Production

Ammonia Gas Production

Methane Gas Production

H2S Production

Bile Acid Metabolism

TMA Production

Uric Acid Production

Putrescine Production

Salt Stress Pathways

Candida Overgrowth

Histamine Overproduction

LPS Production

Precision nutrition interventions improve health outcomes by analyzing gut & oral microbiome functions using machine learning

1. We analyze your chemistry using system biology approach

Our body is a discrete package of multiple biological & cellular processes continuously evolving. A wave of molecular, immunologic, microbial & metabolic pathways is impacted by interaction between nutrition, external environment & microbiome & metabolites secreted as a result of this interaction, which programs our biology for either health or disease.

We take a unified system biology approach that measures & tracks microbial pathways to decipher molecules being secreted indicative of chronic diseases & how they can be modulated or suppressed using nutrition as medicine.

2. We focus on functions of gut & oral microbiome, not their taxonomy alone

Microbial ecosystem, right from top to the bottom of digestive tube, directly impacts your physiology be it digesting food, absorbing nutrition, neutralizing toxins, regulating hormones, modulating glycemic response, training your immune system & brain, regulating energy, producing neurotransmitters & more. Functions of microbiome are linked with pathogenesis of a range of chronic diseases & cancer.

It is a misnomer to categorize microbes as good or bad! Microbes have the capability of producing both good & pro-inflammatory chemicals depending upon the food you ingest. Microbes can sense the substrates of the food you eat & can express certain genes which code for certain proteins that could either secrete beneficial metabolites or harmful toxins.

3. DNA has no connection with progression of chronic diseases

Your genes are static & have no direct connection with onset & progression of chronic diseases. Even when a genotype increases the risk of a disease, it’s the environmental triggers that alters the expression of genes & stimulates production of a particular protein that triggers disease onset.

4. Advanced Machine Learning Engine- PROTEBA

PROTEBA is continuously learning with new scientific discoveries. Everytime a new customer signs up for either gut or oral microbiome solution via our system biology platform, it further makes the results for every future customer more precise.

5. How do we incorporate new learnings into our platform?

New scientific literature such as those related to connection of various microorganisms with range of chronic diseases & genomes of newly classified organisms.

Results & insights from new clinical studies

New machine learning human biology models developed & engineered using the existing & new scientific literature & data gathered from current commercial & clinical samples

Next Generation Sequencing Technology

We use the most advanced sequencing technology to study the downstream functions of gut & oral microbiome. The technology coupled with bioinformatics allows us to transform the molecular data into multiple ( 40 +) pathways. Since each of the pathways correspond with a specific biological function, we could correlate each pathway with a specific health conditions.

Machine Learning

Our machine learning driven human biology algorithm which backs our system biology platform- PROTEBA, is curated & trained by relevant existing scientific literature, knowledge from subject matter experts, scientists, bioinformatics, molecular data, customer phenotype & longitudinal data. The algorithm mines trillions of data sets to find correlation & causation between the microbiome, their functions, biological processes, health conditions & external triggers. The insights from molecular data mining enables you to quantify your biological pathways, compute precision nutrition mapped with your unique biology & determine disease prediction signatures. This allows us to decipher hard to detect & asymptomatic signals which cannot be identified with conventional diagnostic tests.

How we marry microbial pathways with food substrates & nutrients?

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Brain & Cognitive health

Different neurotransmitters & hormones such as serotonin, GABA which regulates our mood, sleep,neurological health & more are produced by microbes living in the gut. We look at the level of production of each of these hormones to determine which specific food & supplement are going to improve their production. For instance, we include some specific polyphenols to reduce instances of Depression & some specific food extracts or foods naturally having GABA to improve GABA production

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Breath Assessment

Microbes in the mouth can metabolize certain cruciferous vegetables, polyamines rich foods, amino acids such as tryptophan & arginine or citrus fruits & produce metabolites such as Hydrogen Sulphide, Polyamines which could trigger bad breath. We look at the level of each of these pathways to determine if citrus fruits, shellfish or Tofu have to be placed in the superfood, moderate or avoid list.

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Heart Health

Microbes in the mouth produce Nitric Oxide via nitrate-nitrite pathway which has vasodilator effect & regulates blood pressure which has a beneficial impact on heart health. On the other hand, microbes in your gut could produce pro-inflammatory metabolites such as TMAO & PAG which could cause plaque in arteries. By quantifying each of the pathways, we could recommend certain foods &/or supplements which could regulate these scores. For instance, your superfood recommendation could include nitrate rich vegetables such as spinach & Arugula which could stimulate Nitric Oxide Production while foods high in choline such as Kidney Beans could land up in moderate or avoid list if you microbes express high level of TMAO production

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Energy Efficiency

Absorption of certain vitamins such as Vitamin B12, Magnesium, Vitamin B6 is driven by functions of certain microbes in the gut. Besides, certain gut microbes also secretes COQ10. Looking at each of these absorption & pathways score, our recommendation engine could include precise vitamin supplements to improve energy efficiency & overcome bouts of fatigue.

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Digestive Efficiency

When we look at your H2S production activity by gut microbes, certain cruciferous vegetables such as Cabbage, Broccoli may land up in the moderate & avoid list, although these vegetables have ample amounts of vitamins & antioxidants. Our recommendation engine will also recommend some specific food extracts that could regulate or suppress H2S Production.

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Gum Health

When we look at your mucin degradation pathways, we look at activities of certain microbes in your mouth which could degrade mucin & produce fucose & sialic acid. This trigger pro-inflammatory pathways & deteriorates gum health. Our recommendations engine would place some specific polyphenols that could suppress mucin degradation activity. We also look at Oral LPS production when your microbes metabolize sugar in the food you eat. Our recommendation engine may recommend some specific foods high in resveratrol to neutralize this score.

Areas of Focus

Metabolic Disorders

Cardiovascular Diseases

Autoimmune Disorders

Chronic Kidney Disease

Autism Spectrum Disorder

Periodontal Disease