Abstract

Any scientific breakthrough needs rigorous pursuit of discovery which is done in a laboratory setting. We have access to thousands of research papers & can now derive health benefits based on years of research done by scientists studying complex mechanisms to find answers “why” & “how” of various aspects of our health.

Every experiment goes through a lengthy & tedious process to translate the research for the general public. To drive innovation & redefine how we need to address growing epidemic of chronic diseases, we at Genefitletics since inception have been focussed on collecting the right data sets & clinical insights from the existing research as well as conducting clinical validation studies to further advance our knowledge of deep rooted connection between biological functions at cellular level & mechanisms of disease development.

Our unique system biology platform- PROTEBA is home to the most advanced & comprehensive mathematical algorithm that collects, processes, analyse & interacts with the data, drives insights from the clinical validation studies & applies the same to individual consumer’s molecular & phenotype metadata to give a detailed digital footprint of his/her biology at molecular level.

PROTEBA is trained by our team of researchers & translational science experts to tirelessly explore the universe of mammoth molecular data, new clinical studies & evidences, digitize biological information & phenotype metadata, sifts through the complex interplay of molecular & cellular pathways we have accumulated over last 6 years which is uncovering the mysteries surrounding health & longevity.

Every single day PROTEBA helps us learn something new about the human biology puzzle that your body communicates & enable us to decode how we can personalise optimal strategy for your unique biology, leveraging new data points coming from every single consumer like you, fueling our data pipeline & new research in science & technology.

The more people join our program & make Genefitletics a partner in their path to health & longevity, the more efficient & precise PROTEBA becomes, the more we learn & more new & existing customers benefit from the new data points & new discoveries.

The beginning of new wave of precision therapeutics revolution

Our technology has been at the forefront to re-introduce nature to you. Globally there are thousands of people living in the age band of 80-90 who are disease free & healthy at system biology level. Even today we see people living in small towns of India, living a healthy long life. It is nature & environment that has solved the problem from them. Our proprietary technologies are collecting, mining & interpreting relevant molecular & cellular data pipeline & data sets every single day to understand what specific biochemical forces maintain this healthy homeostasis. This learning is translated into human biology models that are applied to your molecular & phenotype metadata to understand “how far” & “why” you are away from the optimal longevity. Our platform then constructs & delivers precision nutritional therapeutics interventions at molecular level to feed your biology with specific foods & supplements, containing beneficial molecules & chemical substrates to achieve that optimal life.

We are excited to announce a new version of our vector matrix driven platform- PROTEBA 3.0 which is bringing the revolution in precision health for science, researchers, us( Genefitletics) & most importantly- YOU- our consumers.

While the following paragraphs deep dives into new features & the cellular analysis pack we have introduced which we can analyse & interpret by extracting & digitizing the molecules from your biology sample, the biggest game change is the “ CONSUMER FEEDBACK LOOP”. Now consumers can track on a real time basis the impact of nutritional therapeutics interventions carved out based on their unique biochemistry on multiple aspects of their health & biochemical processes taking place inside the body.

1.Biological Age-AGEGORITHM

Our biological age feature introduced last month is not just another trend or biological age assessment. For the last 4 years, even when not many people spoke about biological age, our team has been tirelessly working on understanding the biochemical processes & molecular interactions that drive our biological age at cellular level. Our recently conducted internal clinical validation study on 6 billion molecular data points elucidated 425 biochemical pathways that directly triggers gut & oral microbiome driven inflammation, impacts mitochondria, cellular health, & leads to decay in its functions. PROTEBA has built a human biology model that statistically combines these pathways to measure & quantify your biology age based on your molecular data. The biological age is a fully commercialized feature at no additional cost to all those who sign up for our ORAHYG PRO- full body biochemistry solution. The solution also incorporates all the pathways contributing to biological age to include precision nutritional therapeutics interventions your cells need right now to improve your biological age.

2.Cellular Health Score

The chain of factors causing decay in cellular functions & cellular stress has been an unsolved mystery till now. With huge molecular data~ 10 billion at our disposal now backed by deep insights on how different provocative agents could lighten up biochemical reactions causing decay & decline in cellular functions, we can now measure your cellular health which covers cellular senescence, cellular stress & inflammation.  We measure & combine these specific pathways to quantify the impact on:

-Cellular proteostasis(ability to make, fold, deliver, transport & degrade proteins)

-DNA Damage

-Telomere Regulation

-MItochondria Biogenesis

-Stress induced progressive decline in cellular functions

-Unfolded protein response

-Stem Cell & regenerative signalling decline.

If consumer’s status comes as “needs improvement”, our recommendation engine includes certain molecules & supplements that can regulate specific pathways driving progressive decline in cellular functions be it degradation of excess or misfolded protein, modulating hypoxia induced stress, oxidative stress , stimulating stem cell mobilization/differentiation or preventing telomere length shortening. For instance Chamomile, and Bacillus coagulans could be recommended to overcome cellular senescence. Similarly Astragalus could increase the length of your telomeres because a key ingredient in Astragalus activates the expression of TERT (enzymes maintain telomere length). On the other hand, quercetin found in foods such as grapes & apples could activate PGC-1 alpha & curcumin could stimulate expression of PGC-1 alpha as well as p-AMPK.

PROTEBA measures the progressive decline in cellular functions, cellular aging & stress by looking & measuring at specific biochemical pathways that lights up, indicating cells are not coping up with stress, folding, synthesis, transport or degradation of excess/misfolded proteins, cannot drive regenerative signalling, stem cell driven differentiation or mitochondria biogenesis.

-Sushant Kumar, Founder & CEO-Genefitletics

3.Amino acid profile

Amino acid metabolism has been wrongly understood & marketing narrative has been too much focussed on amino acids( protein) consumption rather than their synthesis. This narrative has been used by a number of fitness companies & influencers to upsell their protein supplements or fitness programs. The reality, backed by clinical evidence, is that each amino acid interacts with the body differently for different individuals. Our amino acid metabolism score analyses the absorption level of essential amino acids & helps you understand how your enzymes break down dietary protein into constituent amino acids & how each of the amino acids interacts with the oral & gut microbiome. These interactions lead to production of metabolic byproducts that could either support your metabolic health, immune system & even gut health or lead to production of toxins & inflammatory byproducts that could trigger inflammation & oxidative stress & increase risk of various metabolic, digestive & auto immune conditions. PROTEBA measures the expression level of pathways associated with microbial interactions with different essential amino acids & could decipher optimality or sub-optimality  of each of these pathways. These pathways let our recommendation engine incorporate insights from your unique biochemistry to eliminate or reduce specific amino acids that trigger inflammation & production of uremic toxins while including certain specific amino acids in specific quantities promoting beneficial biochemical functions.

4. IBS detection model

We have recently introduced Irritable bowel disease(IBS) detection model that measures & combines 21 biochemical pathways capturing oral & gut microbial genes expression to detect onset of IBS(IBS-C,IBS-D or IBS-M) at an earliest stage at least 7 years before abnormalities show up in blood tests(CBC, C-reactive protein, antibodies test for IBS, Fecal Calprotectin, Fecal Occult Blood Test). The model, a part of our IBS clinical validation study, has been developed using our proprietary vector matrix method(advanced machine learning technique) by analysing & interpreting 2 billion molecular & phenotype metadata. The model is commercially available at scale for all those who sign up for our ORAHYG PRO-Full body biochemistry solution. The precision nutritional therapeutics program that incorporate 400 plus pathways expression level measured from your molecular data boosts anti-inflammatory pathways such as butyrate & GABA & inhibits pro-inflammatory pathways such as ammonia & oral uric acid production that could prevent onset of IBD or stop its progression.

5. The feedback loop- efficacy improvement

We are now offering Industry first model for feedback loop efficacy improvement that helps you seamlessly measure the impact of interventions & give a transparent picture of your progress-improvement or degradation in different health conditions. This feature allows you to compare the impact of revised interventions on your health status every quarter until you complete one year. The model also fuels our model with new phenotype metadata every quarter which further fine tunes our algorithm for better precision for existing & future customers including you.

Everytime you re-test after 12 months you get a seamless comparison of your health scores vis-a-vis previous health scores, enabling you to quantify improvement in different health conditions at molecular level.

6.Higher precision in your recommendations

Our recommendations engine is very smart with more molecular & phenotype data it processes with every single sample, leading to better precision in creating a precision nutritional therapeutics program for you only aligned with your unique biochemistry. Our precision nutritional therapeutics program is personalized based on your unique biochemical signals at cellular level, disease prediction signals & address the disease from the root.

Your data is accelerating health & longevity revolution

Exponential technologies driven algorithms like PROTEBA 3.0 empower us to decipher what is happening inside your body at molecular level that is programming your biology for either health or disease & what specific nutritional & supplement interventions unique for your biology could stimulate beneficial biological functions & suppress harmful biochemical processes to reinstate cellular homeostasis. Additionally, your biological pathway scores acts as key contributors & baseline information in conducting further clinical validation studies

This essentially means that every data from you & customers like you becomes a building block to identify disease onset signals & develop clinical grade tests that could detect diseases at an early stage & shape the revolution of preventative health & personalized medicine.

The power of latest update to our data driven platform-PROTEBA 3.0 lies in our capability to apply latest research coming up daily & combine it with our exponential technologies, lead with the speed of light at which confluence of science, data & technology benefit the users through our unique crafted molecular insights( & scores) & precision nutritional therapeutics interventions. By uniquely combining our technologies, insights from our consumer database & latest scientific literature, we are making sure that recommendation structured for your unique biochemistry meets your biological needs & optimizes your cellular health.

-Sushant Kumar, Founder & CEO-Genefitletics

Everyday, we are working in a direction that can decipher what your cell & microbiome is doing & what specific signaling molecules are being secreted & protein are expressed by them & what specific nutritional substrates they need to biohack your health.

Those who are interesting in knowing about how our full body biochemistry solution- ORAHYG PRO works & how it could help you rejuvenate your cellular health, please visit : https://genefitletics.com/orahyg/