Abstract
As of today 90% of healthcare Dollars are spent on chronic diseases while our healthcare system as we see today has been designed to address episodic & infectious diseases & those requiring acute care. The healthcare system, at best, can manage symptoms of chronic diseases & to some extent make them more bearable, but not prevent or cure them.
More so because the world is too much obsessed with Human DNA & Human Microbiome Taxonomy while chronic diseases have no connection with genetic code or DNA. If an individual is to sequence his/her DNA when he is sick & when he is healthy, it would be the same. Even if an individual gains weight, develops type 2 diabetes, cardiovascular disease or any other systemic disease, his/her DNA remains the same.
Even a lot of microbiome testing companies have a flawed focus on which microbes & how many copies of microbes are there( diversity & potential), not on their downstream functions which are more important than the name of microbes.
This is biggest gap- Chronic diseases are outcome of changes in biology & chemistry which has still not been understood by the current health system
These changes in biology & chemistry occurred as a result of chronic inflammation due to changes in microbial &/or human genes expression levels( not microbial diversity or Human DNA). This article details out unique system biology platform for healthcare practitioners we have built to mine & analyze 5 million plus of molecular data sets/microbial genes expressed per sample that gives healthcare practitioners comprehensive insights into unique biology of patients at molecular level, which cannot be identified by POC diagnostics, empowering them to prevent the disease & /or improve accuracy of their diagnosis & treatment.
Current healthcare practices leaves a huge precision gap to be filled
The modern healthcare system is really symptom care & adopts a reactive approach. Pharmaceutical & generic nutrition interventions recommended by healthcare practitioners are driven by insights derived from healthcare delivery & point of care diagnostic data that lacks precision & accuracy on multiple fronts
- These data points fail to identify & measure pathogenic processes involved in onset & progression of range of chronic diseases & cancer.
- Healthcare delivery data is not capable to delve deeper down to molecular level to decode & decipher underlying cause of chronic diseases
- The data coming from Point of care Diagnostics & wearables fail to measure 99% of biology- genes expressed & downstream functions performed by human microbiome
- Chronic diseases do not manifest overnight, rather it starts developing 2 decades before symptoms appear with chronic inflammation. There are molecular signatures of these diseases years or decades ago but these signatures are either asymptomatic or hard to detect which means that they cannot be identified &/or would never show up in conventional clinical & POC diagnostics tests. As a result, you & your healthcare practitioners wait for symptoms to appear which you capture & validate through healthcare delivery/plasma diagnostic data & then adopt interventions to suppress these blood biomarkers & manage post disease symptoms.
The uncaptured & addressed data points covering 99% of genes expressed by human microbiome, phenotype meta data & longitudinal data forms part of mammoth data warehouse with petabytes of molecular data. These molecular datasets form the basis for measuring overexpression of proinflammatory molecules- cytokines, chemokines & more which are indicative/predictive of onset & progression of chronic diseases. It is impossible for any human being including healthcare practitioners, doctors, dietitians & nutritionists to decipher these data sets.
Up Till now, healthcare practitioners never had access to exponential technologies to decode huge molecular data sets.
Unraveling & leveraging exponential technologies to empower healthcare practitioners to prevent diseases
We have all the science & tech stack in place to collect these vital molecular data sets, process & analyze them to make sense of this data in order to identify, measure & track upregulation or downregulation of specific proinflammatory molecules that indicates movement towards or away from the disease which were never identified by conventional diagnostic tests.
We at Genefitletics, a consumer biotech company, on the back of its consumer system biology platform- PROTEBA, has built Industry’s first translational science platform for healthcare practitioners:
- The platform encompasses multi omics thet collects & isolates 100 million bytes of molecular data from sequencing saliva( oral microbiome) & Faeces (gut microbiome)
- Cloud Computing that processes these molecular data sets & matches it with functions of genes using its proprietary bioinformatics algorithm, thereby translating into gene expression data sets
- Machine Learning that uses its proprietary machine learning models to measure, analyze & combine various gene expression data sets. These gene expression combinations are scored & transformed into various biochemical pathways, reflecting functions of the microbiome at molecular level. Since each score is associated with a specific biological function, it is correlated with specific areas of health such as oral health, heart health, metabolic health, digestive health & more
BIACCESS, separate from consumer driven system biology platform- PROTEBA, is available to your healthcare practitioners at scale which gives a complete digital footprint of your biology at molecular level covering both oral & systemic health as well as gives access to disease prediction models for type 2 diabetes, cardiovascular diseases & autism spectrum disorder.
The platform also compute & inform precision disease modifying nutrition interventions
For healthcare practitioners, including doctors & nutritionists, willing to partner with us to get complete digital picture for their patients including the downstream functions of gut & oral microbiome, please reach out to us at support@genefitletics.com
Those willing to subscribe to our system biology platform for either gut or oral microbiome, please reach out to us at sales@genefitletics.com
