Early detect test for Oral cancer(OSCC)
ORAONCO is India’s premier at-home test that identifies, measures & detects early & pre-tumour molecular signatures associated with early stage oral cancer. The test is also available for preventive recurrence of those in advanced stage of disease &/or undergoing standard of care therapies. The service also includes guidance of healthcare practitioner whenever needed.
- Easy at home biological sample collection
- Measures 7 molecular mechanisms underlying 27 oral microbial pathways associated with oral cancer onset
- Higher precision & accuracy over other screening methods
- Healthcare practitioner guidance
- Access of molecular insights
- Precision nutritional therapeutics to eliminate carcinogenic & mutagenic molecules before cancer proliferates
- Predictive Glycemic Response to 300+ foods
- Blends nutritional therapeutics & standard of care therapies for preventive recurrence
- Real time monitoring of progress at regular intervals to revise the interventions aligned with current state of biochemistry
- Efficacy mapping via clinical validated questionnaires to assess the impact of the nutritional therapeutics program on health outcomes
- Personalised nutrition planner to plan your nutrition schedule, eliminating need of nutritionists & health coaches
This is not an FDA approved or cleared test
Half-Yearly subscription: Rs.35,000 Rs. 27000
(inclusive of GST & other applicable taxes)
At home Testing Process
Who is this Test for?
Early detection of molecular signs of mitochondria dysfunction is the key
Detecting underlying causes of cancer at an earliest stage improves the chances the success & prevents recurrence
< 40% survival rate with late detection
85% survival rate with early detection
< 30% patients are diagnosed early
A solution for deciphering root cause & early detection
Oral cancer(OSCC) is major type of oral & neck cancer.
- 1,00,000 Indians are diagnosed with oral cancer every year
- India accounts for ⅓ rd of global incidence
Currently, healthcare system lacks effective diagnostic tools & access to molecular data to detect cancer at an earliest stage, leading to poor prognosis, late diagnosis, adverse health outcomes & poor survival rates.
The present screening practices are restricted to visual examination or invasive biopsies which fails to identify early molecular signatures, rely only on PET SCAN to detect tumours & fails to identify intertumoral & intratumoral heterogeneity.
What’s Included?
Oral Microbiome Sequencing
Access to detection results via our cancer detect platform
Nutritional therapeutics for prevention
Nutritional therapeutics + standard of care therapies for preventive recurrence
Healthcare practitioner Guidance
If not detected
If no molecular signals indicate you are not moving towards developing OSCC, we recommend you to follow your nutrition recommendations carved out for your biology & discuss your report with your healthcare provider. You could also have access to our healthcare practitioners, if needed. You have an option to retest after 6 months.
If detected
If molecular signals indicate you are moving towards developing OSCC, our translational science team will contact you to explain your results & associated therapeutics interventions. For preventive recurrence, Genefitletics will collaborate with your healthcare practitioner to blend precision therapeutics and standard of care cancer therapies. We recommend retesting after 6 months of following your recommendations.
Insights included with ORAONCO
ORAONCO provides you & your healthcare practitioners with unique molecular insights related to biochemical functions performed by your oral microbiome. Unlike other companies who focussed on composition, our sequencing + machine learning technology enables us to measure molecular activity of oral microbiome to identify pre-lesion signals for oral cancer.These molecular pre-cancer signals empowers healthcare practitioners to align their prognostics & cancer prevention & tumor elimination therapies with your unique biochemistry, thereby improving the survival rate.
The following seven biological mechanisms, encompassing 27 biological pathway scores, based on functional activity of your oral microbiome are combined mathematically to detect onset & progression of oral cancer.
Oral Microbial metabolism of sulfur containing amino acids triggers secretion of volatile sulfur compounds(VSC) which is the main reason for periodontal disease & halitosis. The over expression of enzymes & microbial genes that produce VSC increase tumour survival & promote tumour dedifferentiation. A higher activity level of this molecular mechanism is an indication of movement towards tumour development & growth.
Pro-inflammatory metabolites secreted by oral microbiome provide evidence for a dysbiosis model for role of oral microbiome in development of oral cancer(OSCC). We look at 11 microbial pathways that trigger pro-inflammatory activities favoring carcinogenesis.
Certain commensal microbes living in the oral cavity promote innate immunity by suppressing pro-inflammatory activities as well as promoting anti-inflammatory stuff such as bacteriocin & oral biofilm that suppresses virulence microbial activities involved in periodontal disease. We measure these activities to predict onset & progression of cancer.
Protein fermentation is a byproduct of your oral microbes synthesizing different amino acids that creates a favourable environment for growth of tumour & cancer cell proliferation. Altered Polyamines & ammonia metabolism is involved in transformation & tumor progression. We measure the level of production of these fermentation byproducts to assess the movement towards or away from cancer.
Altered glucose, amino acid & lipid metabolism is involved in feeding the cancer cells which uncouples glycolysis from TCA cycle and oxidative phosphorylation.As a result, glycolysis-derived pyruvate is diverted to lactate fermentation and kept away from mitochondrial oxidative metabolism The intermediate glycolytic metabolites provide essential anabolic support for cell proliferation and tumour growth. We measure level of these metabolites & altered energy metabolism to predict the onset of oral cancer(OSCC).
Detoxification mechanisms are required for various cellular processes including cell differentiation, proliferation, and apoptosis. Dysregulation or low level of detox mechanism pathways are implicated in the development of oral cancer(OSCC). We measure all the pathways involved in the detox mechanism & identify their functions in protecting against reactive oxidative species, reactive electrophilic species & other heavy metals to assess the movement towards or away oral cancer.
Exposure to volatile organic compounds & genotoxic material increases toxicity burden of cells & increase cancer causing potential. We look at these pathways to detect the onset & progression of oral cancer.
PROTEBA- Our Human Microbiome Therapeutics Platform
Our platform boasts of marrying system biology with machine learning to deliver disease modifying outcomes.
Our system biology approach includes mining millions of data sets collected from next generation sequencing technology & converting them into biological pathways which is the starting point of investigating range of chronic diseases.
We have build human biology models that uses our proprietary mathematically drawn machine learning algorithm to combine biological pathway data, customer phenotype data & scientific & clinical literature in order to arrive at biological pathway scores, health insights & pre-symptomatic molecular signatures predictive of chronic diseases.
Our machine learning models marries the activity level of various biological pathways with molecular ingredients in food to arrive at precision nutrition & hygiene interventions to restore your overall health.
CAP Certified
Your sample is analyzed in an Indian CAP certified laboratory to meet CAP standards which is testimony of accurate results.
Data Privacy
To ensure the confidentiality of your data, we safeguard user’s molecular & longitudinal data and use multiple layers of encryption aWe do not provide your information or results to employers or health insurance. Genefitletics never sell your data to third parties
Frequently asked questions
ORAONCO analyzes the biochemical functions of oral microbial species from the molecules collected from saliva samples to detect pre-lesion biological signals associated with oral cancer. Our test blends 22 functional pathways that provide an indication for a person moving towards or away from oral cancer.
The test provides an output which classifies a person likely /unlikely to have oral cancer(OSCC). The results signify any/all detected molecular signatures of oral cancer. In case , the cancer is early detected, our empanelled healthcare practitioner will explain to you all the results in detail.
The test is not meant for diagnosis and should be interpreted in conjunction with other laboratory evaluations and relevant guidelines on the decision for confirmatory diagnosis, such as a biopsy.
The test will quantify all functional pathways as well as detect development of oral cancer. Besides, you will get access to our healthcare practitioners as well as precision therapeutics interventions.
You have the option to either sign up directly or be recommended by one of the empanelled doctors.
Important Information
The test is intended to be used as a tool to evaluate the biological signals associated with OSCC.
ORAONCO is recommended for adults with medium to high risk for oral cancer, type 2 diabetes, obesity or hypertension & those with history of smoking, chewing tobacco, vaping, alcohol consumption , or individuals with a high risk of HPV. ORAONCO only tests for oral cancer should be used in conjunction with routine tests such as biopsy, PET scans & other investigations as recommended by your healthcare provider.
Results should be interpreted in relation to medical history and current symptoms. In order to evaluate your risk, you should re-test every 6 months as result “ not detected” does not rule out cancer. A test result of “DETECTED” requires confirmation via diagnostic evaluation such as biopsy or histopathological methods to confirm cancer.
