Imagine an ecosystem where you find chronic diseases & cancer a topic in history books, not in lives of current & future generations
The current dogma of molecular biology should be driven by expression of genes not static DNA
The static DNA- be it human or microbial does not define the epigenetic changes in biochemistry before the disease onset. The interaction between the external environment & human microbiome triggers expression of genes that codes for a protein that inhibits or stimulates a series of biochemical functions which programs human biology for either health or disease. Working at the confluence of next generation sequencing & machine learning, Genefitletics is revolutionising the future of precision nutrition & disease modifiable therapeutics. Going beyond static DNA & irrelevant healthcare delivery data, Genefitletics collects, processes, analyses & translates molecular data to elucidate early molecular signatures for a range of chronic diseases & cancer & identify therapeutics targets to establish metabolic homeostasis.
Your body gives signals years before Symptoms Develop
Intersection of system biology & exponential technologies allows us to measure hard to detect early signals for metabolic diseases & cancer & deliver disease preventing nutritional therapeutics interventions.
Genefitletics System Biology Platform
Our platform that works at the intersection of next generation sequencing, cloud computing & machine learning collects & mines 10 million molecular data points per sample to identify a deep rooted causation relationship between chronic inflammation & range of chronic diseases & cancer. This enables us to understand, measure & quantify early molecular signatures in order to predict/detect diseases.
From molecular insights to Precision Therapeutics
Genefitletics is transforming human biochemistry into Molecular Data Architecture
10 million molecular data + 2,00,000 longitudinal metadata per sample
We sequence & measure 10 million molecules from gut & oral microbiome genes expressed per sample that allows us to translate molecular data into quantified cellular & biochemical pathways. This allows us to construct data driven precision therapeutics interventions that stimulate anti-inflammatory pathways & suppress pro-inflammatory pathways that establish cellular & metabolic homeostasis.
Where we look for molecular signals?
Gut microbiome- the ecosystem of microbes in the large intestine enjoy a symptomatic relationship with your biology. Research & evidence has found that gut microbiome derived metabolites play a pivotal role in program your biology for either health or disease.
Genefitletics goes beyond microbial DNA & which microbes are there & measures & quantifies behaviour & downstream functions performed by microbes- bacteria, fungi, viruses, phages & yeast living in your mouth & gut. Our analysis takes into account 400 plus biological pathways encompassing 10,000 plus biochemical functions at molecular level to provide precision nutrition, supplements & biotics interventions to optimise the interaction between your gut/oral microbiome & your unique biology.
We do not categorise microbes as good or bad as many commensal microbes could perform beneficial or harmful functions based on what genes they express. Rather we categorise them as doing harmful activities or beneficial activities based on their interaction with external environment/triggers.
The most dense microbiome ecosystem inside our body, oral microbiome performs a key role in not only keeping our mouth healthy, regulating our oral pH level & remineralising teeth but also has a potent role to play in overall health.
Imbalanced oral microbiome could lead to biofilm formation, plaque development. Excess plaque formation could become breeding ground for pathogens & make them secrete toxic byproducts in the mouth & bloodstream which could lead to leaky gut, range of oral diseases & systemic health issues such as Alzheimer's, type 2 diabetes, obesity, cardiovascular diseases, IBD & more
No, microbes in our mouth are important & play a key role in various biochemical processes. It is imbalanced oral microbiome, triggered by interaction between oral microbiome & external environment, could lead to inflammation & poor oral & systemic health.
Your mitochondria, the energy powerhouse of your cells, produce ATP, the energy currency of your cells that gives your cells enough energy to perform various tasks, clear metabolic waste, and toxins. If your mitochondria is not efficient, it cannot deliver energy for your cells to meet up your metabolic needs.
When your mitochondria releases ATP, it also secretes ROS, free radicals that can cause oxidative stress. However our cells also produce glutathione that neutralises oxidative stress. While your gut microbiome also produces antioxidants when they metabolise foods high in polyphenols which becomes super important in case your cells are not producing enough glutathione.
When your biology lacks cellular precision to transport energy sources to mitochondria or your mitochondria is dysfunctional due to ongoing inflammation, oxidative stress, toxins & more, it cannot meet your energy demands & you may experience brain fog, fatigue, pain & a number of system health issues.
Mitochondria dysfunction also leads to production of ROS instead of ATP which could lead to DNA, lipid & protein damage. This makes your body lose the ability to reproduce new cells & replace old cells with new ones, causing ageing. DNA damage is considered as key factor in onset & progression of various chronic diseases including cancer*
*coming soon
Genefitletics Cancer Diagnostics
Translating cancer pathways & molecular signatures into carcinogenic & mutagenic eliminating therapeutics interventions
Genefitletics Research & Development initiatives focussed on early detecting hard to identify Metabolic Diseases & Cancer
Integration of molecular insights from our full body biochemistry & gut microbiome solutions & mining them using machine learning human biology models is improving our understanding of changes in biochemistry before the disease manifests & associated therapeutics that can re-establish metabolic & cellular homeostasis.