Predict onset & progression of type 2 diabetes with PREDIGLYM
With our machine learning algorithm, you could identify specific molecular pathways that are disrupting insulin signalling & dysregulation your blood sugar response
ORAHYG Pro-Full Body Biochemistry solution
Our unique test measures your gut & oral microbiome & cellular functions to optimise your health & promote longevity
Our full body biochemistry solution empowers
- You & your healthcare practitioners with deeper insight about oral & gut microbiome at molecular level as well as mitochondria health,
- Identifies hard to detect early molecular signatures for chronic diseases
- Provides most comprehensive health insights & scores
- Delivers data driven precision therapeutics interventions
- Easy at home biological sample collection
- Detailed view of your overall health at molecular level via 70 plus biological pathways scores & 10 whole body scores
- Decode underlying cause of range of chronic diseases
- Access of computational biology platform for healthcare practitioners
- Predict onset of type 2 diabetes, cardiovascular diseases, chronic kidney disease & halitosis
- Predict insulin response to 300 plus foods, making CGM redundant
- Molecular Data driven precision nutrition, supplement, biotics & oral hygiene interventions
- Support health functions tied to oral health, gut health, brain health, metabolic health & more
- Real time monitoring of progress at regular intervals to revise the interventions aligned with current state of biochemistry
- Efficacy mapping via clinical validated questionnaires to assess the impact of the nutritional therapeutics program on health outcomes
- Personalised nutrition planner to plan your nutrition schedule, eliminating need of nutritionists & health coaches
Sample collection: Saliva/Stool + blood*
*(coming soon)
Health Scores: 72
Results: in 4 weeks
Prediction Models: 4
Annual subscription: Rs.35,000 (inclusive of GST & other applicable taxes)
Age : 9+
At-home Testing Process
Sign-up for the service & receive your kit
Collect your biological sample
Fill up your phenotype assessment form
Receive your health insight & scores + personalised recommendations
What’s covered?
Gut + Oral Microbiome + cellular health
Get a digital twin of your oral biology at molecular level & precise mechanisms of action for the healthier you with Asia’s first & only system biology platform that analyzes downstream biochemical functions of oral + gut microbiome.
You will get 70 plus personalised molecular health insights & scores that tells your current state of health at molecular level, identifies early molecular signatures for range of chronic diseases & forms basis of personalising nutrition as medicine.
We will exhibit how nutritional therapeutics interventions based on your unique biochemistry can suppress the pro-inflammatory activities & promote beneficial biochemical functions, thereby bringing overall improvement in brain, cognitive, metabolic, gut, heart, oral, sexual & immune health. Our recommendations are designed to empower your body to fight with stress & different toxins, thereby impacting how you age biologically.
Our cutting edge technology, backed by existing scientific literature, blends next generation sequencing & machine learning(mathematics) to deliver unique health insights & precise recommendations for nutrition, supplement, biotics & oral hygiene. The recommendations are based on current & latest development in the world of microbiome science which makes sure that the nutrients recommended to you meets your biochemical needs at molecular level.
When you go for the re-sequencing after 12 months, you could track how your recommendations tamed down inflammation & improved your biological pathway scores.
- Gut Health
- Oral health
- Skin Health
- Heart & Metabolic Health
- Brain & Cognitive Health
- Stress Response
- Immune System Health
- Hormonal Health
- Inflammation Response
- Energy Efficiency
- Oral H2S
- Oral Methyl Mercaptan Production
- Oral Polyamines Production
- Oral Ammonia Production
- Oral Urease Pathways
- Oral Butyrate Production
- Oral Inflammatory Pathways
- Oral Nitric Oxide Production
- Oral Cavities promoting pathways
- Butyrate Production
- Oxalate Metabolism
- Histamine Overproduction
- Antioxidant Score
- LPS Production
- TMAO Production
- Cellular senescence
- Cellular stress
- Energy efficiency
- Immune Health
- Biological age
- Triglyceride homeostasis
- Arginine Metabolism
- Lysine Metabolism
- Threonine Metabolism
- Tyrosine Metabolism
- Tryptophan Metabolism
- Phenylalanine Metabolism
- Histidine Metabolism
Unravelling your molecular biochemistry-What we Measure?
Gut microbiome- the ecosystem of microbes in the large intestine enjoy a symptomatic relationship with your biology. Research & evidence has found that gut microbiome derived metabolites play a pivotal role in program your biology for either health or disease.
Genefitletics goes beyond microbial DNA & which microbes are there & measures & quantifies behaviour & downstream functions performed by microbes- bacteria, fungi, viruses, phages & yeast living in your mouth & gut. Our analysis takes into account 400 plus biological pathways encompassing 10,000 plus biochemical functions at molecular level to provide precision nutrition, supplements & biotics interventions to optimise the interaction between your gut/oral microbiome & your unique biology.
We do not categorise microbes as good or bad as many commensal microbes could perform beneficial or harmful functions based on what genes they express. Rather we categorise them as doing harmful activities or beneficial activities based on their interaction with external environment/triggers.
The most dense microbiome ecosystem inside our body, oral microbiome performs a key role in not only keeping our mouth healthy, regulating our oral pH level & remineralising teeth but also has a potent role to play in overall health.
Imbalanced oral microbiome could lead to biofilm formation, plaque development. Excess plaque formation could become breeding ground for pathogens & make them secrete toxic byproducts in the mouth & bloodstream which could lead to leaky gut, range of oral diseases & systemic health issues such as Alzheimer’s, type 2 diabetes, obesity, cardiovascular diseases, IBD & more
No, microbes in our mouth are important & play a key role in various biochemical processes. It is imbalanced oral microbiome, triggered by interaction between oral microbiome & external environment, could lead to inflammation & poor oral & systemic health.
Your mitochondria, the energy powerhouse of your cells, produce ATP, the energy currency of your cells that gives your cells enough energy to perform various tasks, clear metabolic waste, and toxins. If your mitochondria is not efficient, it cannot deliver energy for your cells to meet up your metabolic needs.
When your mitochondria releases ATP, it also secretes ROS, free radicals that can cause oxidative stress. However our cells also produce glutathione that neutralises oxidative stress. While your gut microbiome also produces antioxidants when they metabolise foods high in polyphenols which becomes super important in case your cells are not producing enough glutathione.
When your biology lacks cellular precision to transport energy sources to mitochondria or your mitochondria is dysfunctional due to ongoing inflammation, oxidative stress, toxins & more, it cannot meet your energy demands & you may experience brain fog, fatigue, pain & a number of system health issues.
Mitochondria dysfunction also leads to production of ROS instead of ATP which could lead to DNA, lipid & protein damage. This makes your body lose the ability to reproduce new cells & replace old cells with new ones, causing ageing. DNA damage is considered as key factor in onset & progression of various chronic diseases including cancer*
*coming soon
Combination of external insults & interaction between your microbial cells & improper nutrition results in systemic inflammation, oxidative stress & damage to DNA, mitochondrial dysfunction & disruption of bioenergetics & secretion of pro-inflammatory biomarkers.
This could result in cellular senescence & vice versa, disrupting cells ability to recycle old worn out parts, replicate & reproduce new cells & even fail to deal with normal wear & tear. This inflammation led aging called inflammaging could directly impact functioning of cells, tissues & organs & make you susceptible to age related diseases.
This essentially means that your cells, tissues & organs start to deteriorate & age. Summation of these changes in the aging process, how your body ages, referred to as biological age could surpass our chronological age.
We combine & quantify your pro-inflammatory molecular markers to assess your biological age relative to your chronological age & deliver nutritional therapeutics interventions that can slow down your aging & promote longevity.Why test with Genefitletics?
Benefits offered by ORAHYG PRO
Understanding biochemical processes taking inside the body & feeding your microbiome & cells with the right nutrients is key to fend off toxins, prevent production of pro-inflammatory molecules & stimulate production of beneficial byproducts in order to optimise health & longevity.
Combination of right food, nutrients, biotics & oral hygiene could make a spectacular difference in your energy levels & how you look, feel & age.
Inflammation is your body’s natural response to an external or internal threat. However when your body is under continuous threat, it enters a state of low grade chronic inflammation. This increases risk of chronic diseases including obesity, type 2 diabetes, cardiovascular diseases & poor gut & oral health. Over a period of time, this damages various body organs including the digestive system. Genefitletics measures & quantifies various pathways causing inflammation & delivers interventions that aims at suppressing the inflammatory activity.
Your immune system should be perfectly programmed to prevent external attack such as viruses while it should not be overactive as it could lead to systemic inflammatory cascade. Various biological pathways scores identify the level of inflammation from multiple factors as well as tell the level of immune system response through “ immune system health score”. This allows our algorithm to recommend nutritional ingredients that can eliminate inflammation & right size the immune response.
Your oral microbiome synthesises inorganic nitrate into nitrite which is protonated in stomach acid to produce nitric oxide. Nitric oxide is a vasodilator & regulates blood pressure. We measure your nitric oxide production & deliver interventions that can boost its production to regulate blood pressure. Besides, Kidney function impacts heart health as it filters out harmful metabolites that can damage blood vessels & elevate blood pressure. Gut microbiomes can produce certain metabolites such as Indoxyl Sulphate & p-cresol which could cause oxidative stress & impact kidney function. We measures metabolites produced by gut microbiome & carve out interventions that suppresses these harmful metabolites while improves ability to produce antioxidant that can reduce oxidative stress.
Your gut microbiome stimulates production of various neurotransmitters such as serotonin & GABA that regulates your mood. We measure & monitor your serotonin & GABA production & recommend foods that can boost the production of these neurotransmitters. Nitric oxide produced by your oral microbiome is part of the signalling cascade of endocrine glands that controls how much or how little of each hormone has to be produced. Looking at your nitric oxide production, we recommend foods that boost its production & regulate signalling cascade required for hormone production such as thyroid.
Weight gain or obesity is not about calorie deficit but caused by low grade chronic inflammation. Your gut microbiome could produce certain metabolites such as Butyrate, Acetate & influence production of leptin, ghrelin & GLP-1 that regulates your satiety & food cravings. We monitor & influence these pathways by recommending certain foods to promote healthy weight management.
Continuous glucose monitoring machines(CGM) can track your blood sugar fluctuations in response to a particular meal but it fails to measure glycemic response to some specific molecules in a particular food or combination of certain molecules in different foods. Besides, CGM cannot identify specific changes in cellular response causing glucose spikes.
On the other hand Hba1c is last stage of metabolic syndrome & it cannot identify changes in fasting insulin & glucose which is starting point of type 2 diabetes.
Overcoming the pitfalls in the current standard of care diabetes management practices, our machine learning model measures your gut & oral microbiome functional pathways & genes expressed by them to predict your insulin response to 30,000 food substrates that can pinpoint specific food substrates triggering spikes in insulin.
These specific spikes are incorporated in our data driven precision nutritional recommendations with foods being classified as regular spike, medium spike, high spike & elevated spike.
PROTEBA- Our Human Microbiome Therapeutics Platform
Our platform boasts of marrying system biology with machine learning to deliver disease modifying outcomes.
Our system biology approach includes mining millions of data sets collected from next generation sequencing technology & converting them into biological pathways which is the starting point of investigating range of chronic diseases.
We have build human biology models that uses our proprietary mathematically drawn machine learning algorithm to combine biological pathway data, customer phenotype data & scientific & clinical literature in order to arrive at biological pathway scores, health insights & pre-symptomatic molecular signatures predictive of chronic diseases.
Our machine learning models marries the activity level of various biological pathways with molecular ingredients in food to arrive at precision nutrition & hygiene interventions to restore your overall health.
How our microbiome therapeutics as a service fares up with other microbiome & DNA tests?
Although DNA can tell about ancestry & rare genetic disorders, it cannot decode current health symptoms. DNA does not change during life & hence food interventions based solely on DNA does not change even if an individual experiences health issues. The underlying cause of multiple health issues is generally altered genes expression which is driven by human microbial functions.Genefitletics decodes & analyze microbial functions at molecular level & transform them into biological pathways to offer nutrition, supplement biotics interventions to help you bring back body in state of balance.
Most Microbiome testing companies, unlike Genefitletics, are just focussed on microbial DNA & can only tell you which microorganisms are there in the gut. They cannot decode functions of these microbes inside the gut, what they are doing, what they are producing, their activities & behavior. For instance, two people suffering from type 2 diabetes may have completely different organisms but these organisms produce the same metabolite that causes type 2 diabetes. These tests cannot even tell if those microbes are active or dormant.
Genefitletics ‘s microbiome therapeutics as a service decode functional activity of microbiome & gives a complete picture of metabolites being produced by microbiota such as production of beneficial byproducts- butyrate, antioxidants, vitamin & minerals & release of harmful toxins such as LPS, TMA, Methane, Ammonia, Putrescine & more.
Food sensitivity tests measure antibodies to foods. Foods that are listed on your food sensitivity tests may be actually good for you. You may be eating a lot of that food while suffering from intestinal permeability aka leaky gut. Leaky gut is the outcome of prolonged chronic inflammation that damages gut lining, allowing a lot of food particles & even bacteria to cross the barrier & enter the bloodstream & making the immune system release antibodies in response to those foods, bacteria or any other substances. The food sensitivity reactions are Ig mediated immune system responses causing inflammation & triggering symptoms such as bloating,constipation, headache, migraine & more.
