Connection between your microbiome & diabetes
Monitoring blood sugar level can be an uphill task especially when current understanding of nutrition has failed to transform personalized nutrition approach to an optimal diet that can suppress the biological mechanism that causes type 2 diabetes.
The interaction between your body & the food you eat has a profound impact on your blood sugar levels. This is the reason why glycemic index may not be the correct selection criteria to choose the right foods to de-escalate your blood sugar levels.
Scientists have found that your gut microbiome can impact how your food affects your blood sugar and how much energy you get from your diet.
Besides, there are multiple other factors that trigger onset & progression of this metabolic syndrome besides hyperglycemia. Research has found that high growth of Yeast- candida, vitamin D & magnesium deficiency, low antioxidant absorption, disruption in gut- brain communication & release of toxins by gut microbiome such as LPS,TMA, Ammonia or Putrescine can trigger insulin resistance, precursor for type 2 diabetes. Disruption in all these biological mechanisms is connected with gut dysbiosis.
A healthy & resilient gut microbiome is associated with rich & diverse balance of microbiome as well as production of beneficial compounds that promotes anti-inflammatory molecules & suppressed pro-inflammatory compounds
Standard of Care Blood Works & Type 2 Diabetes
High glycated hemoglobin (HbA1c), the standard-of-care marker for prediabetes and diabetes have been used for years to investigate your blood sugar levels & carve your nutrition & therapeutic interventions to prevent its spike. However tracking these blood markers are far away from developing novel mechanisms to prevent & reverse type 2 diabetes.
High glycated hemoglobin(HbA1c) is the last stage of metabolic disease. Type 2 diabetes starts developing 15 years earlier. During gut dysbiosis,interaction between your gut microbiome & the food you eat creates a condition when first your fasting insulin goes up, then fasting glucose goes up & finally HbA1c goes up. The focus should be on preventing spikes in fasting insulin in the first place. Controlling & reversing HbA1c does not equate to reversing type 2 diabetes
Besides, there are multiple challenges in using high glycated hemoglobin to optimize your glycemic response.Your biological sample goes through 40 different steps before it is processed. The way your biological sample is collected, transported, stored & processed have a direct impact on test results & therefore the results can lack accuracy & precision. In addition, these tests can tell if your blood sugar is disrupted but it does not provide your healthcare practitioners the right set of biological information to help them decode the underlying cause of the spike. Similarly, continuous glucose monitoring machines(CGM) can track your blood sugar fluctuations but do not provide the precise underlying cause of such fluctuations. These underlying causes can be high glycemic response, escalated cortisol production, low antioxidant absorption or yeast overgrowth
These root causes can be understood by measuring secondary metabolites released by your gut microbiome as a result of bacterial metabolism of the food you eat..Some of the microbial metabolites that directly impact fasting insulin level includes butyrate production, LPS Production, Cortisol Production, antioxidant production, Ghrelin production & candida overgrowth. Therefore understanding how your gut microbiome interacts with the food you eat is the building block to regulate your fasting insulin levels.
How Genefitletics can empower you to regulate your fasting insulin levels?
Your gut microbiome consists of trillions of bacteria that can help you digest foods & absorb nutrients your body needs. Depending upon your nutrition choices, microbes residing in your gut can metabolize the food & either convert into beneficial compounds that prevent insulin spike & regulate your biology or harmful substances that could lead to increased release of glucose in your bloodstream & impact your metabolic rate.
Genefletics can help you decode which foods are right for your biology to regulate your blood sugar level while promoting a healthy weight management.
Genefitletics analyzes your unique biology to give your personalized health insights, precision food, supplements & biotics recommendations in order to regulate your blood sugar level & improve your insulin sensitivity.
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How it Works?
1. Your unique biology, decoded
Your test allows us to collect biological data reflecting activities & behavior of single & multi cellular organisms living in your gut & vagina using our next generation sequencing technology & analyze them using our state of art translational science algorithm-PROTEBA
Composition & functional activity of gut & vaginal microbiome is associated with everything from metabolic diseases, skin issues, hormonal imbalances, digestive disorders, autoimmune diseases, brain & cognitive health, stress response , recurrent infections, endometriosis, PCOS, cancer, UTI to preterm birth & more. Get detailed breakdown & functional activity of all microbes including those missed out by traditional testing methods.
Your biological sample- stool + vaginal swab
Fill up phenotype form
We sequence your biological sample using next generation sequencing tech to find out which microbes are present & what they are doing
Run our algorithm to measure & score your vaginal biological pathways
We are on a mission to demystify human health at the molecular level & address the unique biology of an individual by converging tech with science to get rid of chronic diseases. When you sign up for Genefitletics’ s revolutionary UP THE GUT or VAGECO human biology test to decode your holistic health, you entrust us with your important information & we are inclined towards maintaining your biological data safe & secure.
2. Molecular insights & scores
Comprehensive 13 whole body scores supported by 45 plus sub biological pathway scores that are decoding underlying cause of poor health & onset of chronic diseases at molecular level
Our blend of tech with science allows us to analyze, quantify & track microbial pathways that reveal how each of beneficial or toxin molecules are produced & which biological function in the body is impacted as a result
Whole body comprehensive molecular & biological insights
Your gut microbiome directly communicates with your brain via vagus nerve , aids in development of brain & nervous system & helps in management of neurological functions.
Your nutrition recommendations are carved out to support your brain health & functions that improves your cognitive & mood.
Our molecular & biological functions analysis assesses your:
1. GABA Production
2. Serotonin Production
3. Nutrient absorption that impact your memory & focus
Activities that impact stress & your body’s pH balance.
While many people simply think that having a low carb, high protein diet, quantified nutrition interventions, managing their cholesterol is best foot forward to improve their heart & metabolic health, in reality, many factors are at play, including oxidative stress, endothelial function, kidney function, hormonal health, digestive efficiency and vitamin and mineral status, all of which are influenced by gut microbiome.
Your nutrition recommendations are designed to optimize functions related to your heart & metabolic health.
Our molecular & biological functions analysis assesses your:
1. Activities that promote circulatory inflammation in heart
2. Molecular signatures of metabolic diseases
3. Cholesterol & bile acid metabolism
4. How well your body is digesting proteins
5. Level of antioxidant production
6. Absorption of nutrients that promote cardiovascular health
The byproducts released by gut microbiome when they digest the food you eat is directly available to your skin. Depending upon what is being released, activities of your gut microbiome directly influences your skin health.
Your nutrition recommendations are designed to optimize your skin health.
Our molecular & biological functions analysis assesses your:
1. Skin pH level
2. How well nutrients are supporting skin homeostasis.
3. How skin health is impacting your digestive efficiency
4. How your thyroid hormones & HPA Axis is impacting your skin health.
Interactions between your gut microbiome & the food you eat directly impacts your digestive health. Over activity of some specific opportunistic microbes can trigger bloating, constipation & other uncomfortable symptoms that can directly impact your bowel movements, your nutrition absorption & even increase risk of cardiovascular diseases.
Your nutrition recommendations are designed to improve your digestive efficiency.
Our molecular & biological functions analysis assesses your:
1. Butyrate production
2. Methane gas production
3. H2S production
4. Ammonia gas production
5. Bile Acid Metabolism
6. Oxalate Metabolism
7. TMA Production
8. LPS Production
9. Putrescine Production
Your gut microbiome has a pivotal role to play in regulating various hormones. It isn’t just producing hormones but also telling other glands how much or little of each hormone they should be creating or releasing.
Your nutrition recommendations are designed to regulate your hormone production.
We report on
1. Serotonin Production
2. Thyroid Production
3. Cortisol Production
4. Fight or Flight response
5. Ghrelin Production
A healthy immune system is essential for fighting off outside invaders & pathogens such as viruses, bacteria, and fungi & neutralizing environmental toxins & those coming from the food you eat that lead to a decline in biological functions. Your gut microbiome constantly trains & communicates with your immune cells to inform them of toxins coming from food to take corrective action for neutralizing them.
Your nutrition recommendations are carved out to facilitate right expression of immune cells.
We report on
1. Immune system’s ability to manage & tackle oxidative stress
2. Preparedness to fight toxins & harmful bacteria & microbes
Your microbes can contribute to or reflect inflammation in your gut environment. Inflammation in your gut can be caused by harmful things your microbes produce when protein is inefficiently digested, there's excessive microbial gas production, or you simply have a gut environment that your microbes perceive as threatening.
Prolonged inflammation due to factors such as poor diet, increased stress, and environmental toxins promote health decline.
Your nutrition recommendations are carved out to support anti-inflammatory activities & suppress pro-inflammatory activities.
Molecular interactions between your gut microbiome & the food you eat directly influences your gut microbiome communication with your brain which can impact your stress levels.
Our nutrition interventions are designed to modulate your stress levels.
Our molecular & biological functions analysis assesses your:
1. Stress levels
2. How nutrients are responding to high or low stress levels.
3. How stress levels are connected with metabolic, neurodegenerative, reproductive, digestive health & skin issues.
Activities of your microbiome directly influence efficiency of the functions of your mitochondria that are required to meet your body's energy and metabolic needs. A low energy efficiency means that your cells are not receiving enough energy to function efficiently, resulting in accelerated aging, and poor metabolism, cardiovascular, and brain health.
Our nutrition interventions are designed to make sure that you microbiome is extract all vitamins & minerals to transport fat & carb to mitochondria for it to oxidize, process & metabolize these energy sources & provide necessary energy to cells & tissues.
Your gut microbiome is home to trillions of microbes that have a direct influence on everything from your mood to how you digest foods and even how your immune system responds to infections.
Your nutrition recommendations are designed to regulate your digestion, strengthen gut lining, and improve your microbiome diversity.
What we report on:
1. Microbial activities that are triggering inflammation
2. Intestinal barrier health
3. Nutrient absorption
Your vaginal microbiome is home to billions of microbes consisting of both protective & disruptive bacteria. Composition & activity of protective & disruptive bacteria directly influence the balanced state of your vaginal microbiome. Domination of disruptive bacteria leads to vaginal dysbiosis & increase your risk of recurrent infections & bacterial vaginosis, Aerobic Vaginitis (AV) & Cytolytic Vaginosis (CV).
Your nutrition recommendations are designed to promote the activity of protective bacteria & suppress activity of disruptive bacteria.
While every vaginal microbiome is unique, most vaginal microbiomes fall into one of five general categories, sometimes called "Community State Types” (CSTs). CST evaluates the state of your vaginal microbiome’s composition, what symptoms you may experience, and your risk of developing an infection.
We report on your CST type based on functional activity & composition of your vaginal microbiome.
Our prebiotics & probiotics interventions are focussed on improve the diversity of protective bacteria- lactobacillus & making sure that your CST is either type 1, type 2 or type 5.
Nugent score is calculated to diagnose risk of developing bacterial vaginosis. The score is derived based on the presence of gram positive bacteria, gram negative bacteria & curved gram negative bacteria. A score of 7 & above is indicative of bacterial vaginosis.
Our nutrition interventions are focussed on reducing & optimizing this score.
3. Transform your health insights into nutrition interventions
We will bridge the gap between suboptimal biological functions & the foods you should avoid & minimize & which ones you should consume more to regulate & optimize them
Learn what specific nutrition interventions can bring back your gut & vaginal health into state of balance & overcome chronic diseases & recurrent infections
These interventions are carved out to
- Promote beneficial microbial activities to reduce low grade chronic inflammation.
- Learn why certain foods touted as healthy might be promoting inflammation & feeding pathogens living inside the gut
- Improve absorption of antioxidants that can overcome instances of oxidative stress & overcome susceptibility of developing metabolic diseases.
- Which specific foods can balance your gut microbiome composition & regulate their activities to optimize your mental health, skin health, digestive health, & immune system health
- Increase your energy, focus and well-being.
- Help you achieve and maintain a healthy weight
- Improve activity of microbes associated with improving overall wellness.
4. Introducing precision supplement interventions to regulate your biology
Your precision supplement interventions are carved out to support the biological pathways which are suboptimal right now & your nutrition interventions are sufficient to regulate them due to ongoing chronic & systemic inflammation.
This covers recommendations on how much of each of the following your body & microbiome needs daily,
-Amino acids, vitamins & minerals
-Antioxidants & adaptogens
-Food extracts & postbiotics
-Prebiotics & probiotics
5. Democratize your holistic health
All UP THE GUT & VAGECO unique health insights & health interventions are blended into a research ecosystem which empower healthcare practitioners to align their diagnosis & treatment with the unique biology of an individual.
How you can map your current & future health journey?
We send you a sample collection kit for collecting your stool & vaginal swab. We pick your sample for carrying out its sequencing at our CAP certified lab. Everything you need to collect is included in the kit.
Receive your analysis & results digitally via web/mobile app
We categorize over 320 foods into superfoods, moderate, minimize & avoid list & include 150 precision supplements recommendations covering amino acids, vitamins, minerals, food extracts, prebiotics, probiotics, antioxidants & adaptogen in exact amount/dosage & frequency to help you make right decision for your biology daily for next 4-6 months.
Current Spending on Managing/ Treating Diabetes is High ~ $ 300 (INR 24000) a month
We are here to optimize.!
Diagnostic Tests- $ 31 a month
Antibiotics & drugs- $ 194 a month
Doctor Consultation- $ 13 a month
Nutrition Services- $ 50 a month
Supplements- $ 13 a month
& more
UP THE GUT/ VAGECO
-Decodes functional activity of full stack of gut & vaginal microbiome covering bacteria, fungi, yeast & viruses, archaea, protozoa.
-Determine underlying cause of developing diabetes & recurrent infections.
-Gives unique health insights & biological pathway scores that reflect the current state of overall health.
-Gives precision nutrition & supplement, probiotics, postbiotics & probiotics interventions to overcome inflammation, which is the root cause of diabetes.
-Correlate your symptoms with functional activities/pathways of microbes.
-Track & measure how your gut & vaginal microbiome is responding to your personalized health interventions every time you test.
Starts at $93 – $140 per month
paid 6 months/4 months in Advance depending on plan
