UP THE GUT - Genefitletics

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UP THE GUT- Premium gut microbiome biochemical functions solution

Our unique test measures your gut microbiome functions to decipher underlying cause of chronic inflammation & its impact on systemic health

Our gut microbiome biochemistry solution empowers

You & your healthcare practitioners with deeper insight about gut microbiome at molecular level
Identifies hard to detect early molecular signatures for chronic diseases
Provides most comprehensive molecular insights & scores
Delivers data driven precision therapeutics interventions

Data Collection & analysis

Easy at home biological sample collection
Detailed view of your overall health at molecular level via 26 plus biological pathways scores & 10 whole body scores
Decode underlying cause of range of chronic diseases
Discover your gut microbiome’s response to 300 plus foods & supplements
Access of computational biology platform for healthcare practitioners

Disease Prediction

Predict onset of type 2 diabetes & cardiovascular diseases
Predict insulin response to 300 plus foods, making CGM redundant

Disease modifiable Interventions

Molecular Data driven precision nutrition, supplement & biotics interventions
Support health functions tied to gut health, brain health, metabolic health & more
Real time monitoring of progress at regular intervals to revise the interventions aligned with current state of biochemistry

Technology Tools

Efficacy mapping via clinical validated questionnaires to assess the impact of the nutritional therapeutics program on health outcomes
Personalised nutrition planner to plan your nutrition schedule, eliminating need of nutritionists & health coaches

Sample collection: Stool

Health Scores: 36

Results: in 4 weeks

Prediction Models: 2

Annual subscription: Rs.35,000( inclusive of GST & other applicable taxes)

Age : 4+

At-home Testing Process

Sign for the service & receive your kit

Collect your biological sample

Fill up your phenotype assessment form

Receive your health insight & scores + personalised recommendations in 4 weeks

What’s Covered?

Get a digital twin of your gut microbial biochemistry at molecular level & precise mechanisms of action for the healthier you with Asia’s first & only system biology platform that analyses downstream biochemical functions of gut microbiome.

You will get 36 personalised molecular health insights & whole body scores that tells your current state of health at molecular level, identifies early molecular signatures for type 2 diabetes & cardiovascular diseases & forms basis of personalising nutrition as medicine.

We will exhibit how nutritional therapeutics interventions based on your unique biochemistry can suppress the pro-inflammatory activities & promote beneficial biochemical functions, thereby bringing overall improvement in brain, cognitive, metabolic, gut, heart, hormonal, sexual & immune health. Our recommendations are designed to empower your body to fight with stress & different toxins.

Our mathematics driven recommendation engine backed by existing scientific literature identifies specific ingredients your gut microbiome needs right now & constructs a personalised combination of nutrients, probiotic strains, and prebiotic fibres that modulates your gut microbial pathways & whole body scores.

The recommendations are based on current & latest development in the world of microbiome science which makes sure that the nutrients recommended to you meets your gut biochemical needs at molecular level.

When you go for the re-sequencing after 12 months, you could track how your recommendations tamed down inflammation & improved your biological pathway scores.

Whole Body Scores

Gut Health
Oral health
Skin Health
Heart & Metabolic Health
Brain & Cognitive Health
Stress Response
Immune System Health
Hormonal Health
Inflammation Response
Energy Efficiency

Gut Pathway Scores

Butyrate Production
Oxalate Metabolism
Histamine Overproduction
Antioxidant Score
LPS Production
TMAO Production

& 20 more

Nutrition Recommendations

Your personalized recommendations which cover 317 foods are categorized into superfood, enjoy, moderate & avoid. Given that the program is for 12 months, we revise your recommendations every quarter based on improvement in your symptoms which we capture through our scientifically designed phenotype form. The recommendations are targeted to:

Promote beneficial gut microbiome functions to promote anti-inflammatory activities.
Address underlying factors causing inflammation.
Suppress pro-inflammatory activities such as Ammonia, Putrescine, LPS production & more
Optimise nutrition- vitamin & mineral absorption
Promote microbial activities that stimulates butyrate & neurotransmitter production
Suppress the activities of gut microbes producing toxins & metabolic waste
Rebalance gut microbial functions to minimise the risk of leaky gums
Optimise glycemic response to 300 plus foods using proprietary glycemic response prediction model
Strengthen gut lining to improve digestive health
Suppressing pro-inflammatory activities involved in onset of cardiovascular disease & type 2 diabetes
Eliminate the early inflammatory molecules before type 2 diabetes manifests
Improve energy efficiency by suppressing oxidative stress
Improve skin health
Eliminate bouts of anxiety & depression

& more

Supplement Recommendations

Our precise recommendations for supplements fill in the nutrient gap & meet your cellular needs caused due to current ongoing systemic inflammation. When considering the amount of each ingredient, we look at the activity level of 26 functional pathways & your phenotype & longitudinal data. The supplements recommendations are divided into:

Amino Acids
Food Extracts
Antioxidants
Minerals
Vitamins
Adaptogens

Biotics Recommendations

Precision biotic( prebiotics + probiotics) are computed to stimulate production of beneficial molecules & suppressing pro-inflammatory metabolites, thereby taming down inflammation & improving overall systemic health. We carefully select specific strains, based on existing scientific literature, that aims to overcome issues such as:

Digestive discomfort, bloating, constipation & overall food motility
Gut-brain health
Gut-heart health
Gut-skin health
Immune System Health
Hormonal health

Personalised Nutrition Tableau

Our System biology platform empowers you to plan your daily diet from your precision food recommendations without any human intervention. In other words, you do not need a nutritionist or coach to plan a diet for you.

Where we Focus?

Gut Microbiome

Your gut microbiome is the CEO of your health. These 40 trillion microbes living in your gut aids in digestion & nutrient absorption, produce neurotransmitters, regulate weight, neutralise toxins, provide us minerals, vitamins & short chain fatty acids.

These microbes sense each of the molecular substrates in foods & express a particular gene that codes for proteins that perform a particular biochemical function. Based on this biochemical transaction, microbes may synthesise a particular molecule into beneficial chemical byproducts or harmful toxins that triggers inflammation & triggers onset & progression of disease.

How is Genefitletics different?

Unlike most of the microbiome companies in India, we focus on measuring & quantifying biochemical functions of your microbiome & translate this understanding into various pathways that exhibit levels of beneficial or harmful metabolites being produced. We then recommend nutritional ingredients that can stimulate production of beneficial metabolites & suppress the secretion of harmful toxins.

Key molecular insights UP THE GUT decodes

Goes to the root of Inflammation

Your gut microbes can produce inflammatory metabolites such as TMA which enters the bloodstream & travel to the liver where FMO3(enzyme) converts it into TMAO. This inflammatory TMAO could lead to adiposity, impact your kidney functions & increases risk of atherosclerosis. We measure production of gut derived TMAO & deliver actionable interventions that could suppress the activity of microbes that produces this harmful metabolite.

Does your gut deliver antioxidant benefits?

Some specific microbes living in your gut can metabolise polyphenols, flavonoids & other antioxidants & synthesise into beneficial byproducts such as Urolithin A that can minimise bouts of inflammation & oxidative stress & boost your cellular health. We measure & monitor antioxidant production to carve our nutrition choices that could boost your antioxidant production score.

Are cruciferous vegetables harmful for your biology right now?

Although cruciferous vegetables such as cauliflower or cabbage contain antioxidants that can be a shield against illness, some of your gut microbes, if active & expressing virulence genes could metabolise glucosinolates in these vegetables & synthesise into hydrogen sulphide(H2S) which could cause bloating & digestive discomfort. If we observe your H2S production score is high as measured by analysing functions of your gut microbiome, we will immediately place foods high in glucosinolates & those rich in sulphur containing amino acids in the avoid list. These foods may be reintroduced once the H2S production score is minimised.

We could predict your insulin response to various foods

Using our machine learning, we look at 17 gut microbial pathways that are the culmination of tens of thousands of microbial activities & functions to predict insulin response to 317 foods. The predictive insulin response to foods is mapped with 26 biochemical pathways to construct precision therapeutics interventions that takes into account & minimises/avoids the foods which exhibit moderate to high spike. Every time you re-test, our machine learning model takes into account changes in your microbial pathways activities to reassess the insulin response to the foods & are incorporated in nutrition interventions accordingly.

Are gut pathobionts becoming aggressive in your gut?

Certain microbes in your gut are pathobiont & when given a chance can wage a war with other microbial counterparts. This generally happens when your dietary choices feed those opportunists or when you binge late at night. In such situations, these microbes secrete harmful chemicals & endotoxins such as LPS which inflame your gut, cause overactive immune response or harm your gut lining. We could identify such aggressive behavior by measuring & quantify some specific pathways.

Your Health scores

We provide biological pathways scores based on unique functional activity of your gut microbiome. Unlike other tests that focuses on your DNA, we use functional activity analysis which provides deeper molecular insights of gut microbiome & decode early signatures of range of chronic diseases & cancer.

With these insights & associated nutrition interventions, you can track improvement in molecular signatures indicative of systemic diseases.UP THE GUT is the only test in Asia that converts your gut microbiome functions into molecular insights that can be monitored over time for transformative outcomes.

Brain & Cognitive Health

Skin Health

Immune System Health

Inflammation Response

Energy Efficiency

Heart & Metabolic Health

Digestive Efficiency

Hormonal Health

Stress Response

Gut Health

Mapping your biological pathways with Nutrition, Supplement & Biotics Recommendations

Why test with Genefitletics?

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Personalising nutrition as medicine based on your unique biochemistry

Genefitletics treats nutrition as a blend of science & mathematics. Using our next generation sequencing technology empowers you to go beyond guess work & anecdotal evidence. Our system biology platform measures your gut microbiome functions to identify the specific nutrition needs of your body that suppress inflammation, nourishes your cells & promotes your health & vitality.

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Scientific discoveries & technology at epicenter of our system biology approach

We identify sounds in your biology using our proprietary algorithm that is backed by 35000 existing scientific literature. New scientific literature is added every month.Your data not only benefits your biochemistry but also trains our algorithm & helps every new customer that joins our program with the objective of helping humanity live better lives. We have developed a disease detect platform as a result of discoveries made from molecular insights derived from your & other users data.

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Address the root cause of diseases

Collection & processing 5 million molecular data points & translating them into 100 plus molecular pathways allows us to identify the specific biochemical functions a particular health condition stems from. This overcomes guess work & enables us to target specific metabolites causing inflammation to bring your body back into a state of balance.

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Fix your biochemistry before disease develops

Your body gives signals years before post disease symptoms develop. Your gut microbiome is dynamic & ever evolving & their interaction with external environment alters your biochemistry that triggers asymptomatic inflammatory signals. However, we measure & analyse these inflammatory signals before symptoms manifest. This allows us to recommend foods, supplements & biotics in specific quantities & frequency that eliminate these signals while stimulating production of beneficial metabolites & mitochondria biogenesis.

PROTEBA- Our Human Microbiome Therapeutics Platform

Our platform boasts of marrying system biology with machine learning to deliver disease modifying outcomes.

Our system biology approach includes mining millions of data sets collected from next generation sequencing technology & converting them into biological pathways which is the starting point of investigating range of chronic diseases.

We have build human biology models that uses our proprietary mathematically drawn machine learning algorithm to combine biological pathway data, customer phenotype data & scientific & clinical literature in order to arrive at biological pathway scores, health insights & pre-symptomatic molecular signatures predictive of chronic diseases.

Our machine learning models marries the activity level of various biological pathways with molecular ingredients in food to arrive at precision nutrition & hygiene interventions to restore your overall health.

How our microbiome therapeutics as a service fares up with other microbiome & DNA tests?

DNA Test

Although DNA can tell about ancestry & rare genetic disorders, it cannot decode current health symptoms. DNA does not change during life & hence food interventions based solely on DNA does not change even if an individual experiences health issues. The underlying cause of multiple health issues is generally altered genes expression which is driven by human microbial functions.Genefitletics decodes & analyze microbial functions at molecular level & transform them into biological pathways to offer nutrition, supplement biotics interventions to help you bring back body in state of balance.

Microbiome DNA Test

Most Microbiome testing companies, unlike Genefitletics, are just focussed on microbial DNA & can only tell you which microorganisms are there in the gut. They cannot decode functions of these microbes inside the gut, what they are doing, what they are producing, their activities & behavior. For instance, two people suffering from type 2 diabetes may have completely different organisms but these organisms produce the same metabolite that causes type 2 diabetes. These tests cannot even tell if those microbes are active or dormant.

Genefitletics ‘s microbiome therapeutics as a service decode functional activity of microbiome & gives a complete picture of metabolites being produced by microbiota such as production of beneficial byproducts- butyrate, antioxidants, vitamin & minerals & release of harmful toxins such as LPS, TMA, Methane, Ammonia, Putrescine & more.

Food Allergy Test

Food sensitivity tests measure antibodies to foods. Foods that are listed on your food sensitivity tests may be actually good for you. You may be eating a lot of that food while suffering from intestinal permeability aka leaky gut. Leaky gut is the outcome of prolonged chronic inflammation that damages gut lining, allowing a lot of food particles & even bacteria to cross the barrier & enter the bloodstream & making the immune system release antibodies in response to those foods, bacteria or any other substances. The food sensitivity reactions are Ig mediated immune system responses causing inflammation & triggering symptoms such as bloating,constipation, headache, migraine & more.